Fig. 4

Inhibition of IL-7/IL-7Rα signaling promotes Tregs in peripheral blood. NOD mice were treated and peripheral blood analyzed as in Figs. 1a and 2. a Representative dot plots (left) and summary (right) of frequency of CD4⁺ Foxp3⁺ Tregs within the CD4⁺ T cell population. b Representative histogram (left) and summary of MFI (right) of Foxp3 expression levels within CD4⁺ Foxp3⁺ Tregs. c, d Representative dot plots (left) and summary (right) of PD-1⁺ CD44^high cells (percentage) and Tim-3 (MFI) within the CD4⁺ Foxp3⁺ Treg population. Each symbol represents one individual mouse. All data are representative for two independent experiments. * = p ≤ 0.05, ** = p ≤ 0.005, *** = p ≤ 0.0005