Fig. 4

Snapshot of numerical simulations of the cells and cytokines distribution in lymph node. Different cells are shown: APC (green), naive CD4 ⁺ T cells (black), naive CD8 ⁺ T cells (white), three maturity levels of differentiated CD8 ⁺ T cells (blue), two maturity levels of CD4 ⁺ T cells (yellow). Mature CD4 ⁺ T cells produce IL-2 whose concentration in the extracellular matrix is shown by the level of green. APC produce IFN (red). The upper figure shows the simulation (day 8 post infection) with equal diffusion coefficients of IL-2 and IFN, in the lower figure (day 80 post infection) the diffusion coefficient of IFN is 10 times larger than the diffusion coefficient of IL-2