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Table 2 Genotype distribution and allele frequency of polymorphism in patients with chronic ITP and healthy controls

From: The cytokine polymorphisms affecting Th1/Th2 increase the susceptibility to, and severity of, chronic ITP

  ITP (%) Control (%) P value OR 95%CI Statistical model
IFN-γ Genotype TT 3 (2.4) 2 (1) 0.38 2.44 0.40–14.80 Recessive
TA 15 (11.9) 44 (21.8)     
AA 108 (85.7) 156 (77.2) 0.06 1.77 0.97–3.22 Dominant
Alleles T 21 (8.3) 48 (11.9) 0.15 0.67 0.39–1.16  
A 231 (91.7) 356 (88.1) 1.48 0.87–2.54  
FN-γR Genotypes GG 0 (0) 0 (0) - - -  
GA 11 (8.7) 22 (10.9)     
AA 115 (91.3) 180 (89.1) 0.53 1.28 0.60–2.73 Dominant
Alleles G 11 (4.4) 22 (5.4) 0.54 0.79 0.38–1.66  
A 241 (95.6) 382 (94.6) 1.26 0.60–2.65  
IL-4 Genotypes CC 17 (13.5) 17 (8.4) 0.14 1.70 0.83–3.46 Recessive
CT 56 (44.4) 88 (43.6)     
TT 53 (42.1) 97 (48.0) 0.29 0.79 0.50–1.23 Dominant
Alleles C 90 (35.7) 122 (30.2) 0.14 1.28 0.92–1.79  
T 162 (64.3) 282 (69.8) 0.78 0.56–1.09  
IL-4Rα Genotypes QQ 88 (69.8) 161 (79.7) 0.04 0.59 0.35–0.98 Dominant
QR 37 (29.4) 37 (18.3)     
RR 1 (0.8) 4 (2.0) 0.65 0.40 0.04–3.58 Recessive
Alleles Q 213 (84.5) 359 (88.9) 0.11 0.69 0.43–1.09  
R 39 (15.5) 45 (11.1) 1.46 0.92–2.32  
  1. ITP: immune thrombocytopenia, OR: odds ratios, 95% CI: 95% confidence intervals, IFN: interferon, IL: interleukin, Recessive: Recessive model, Dominant: Dominant model