Table 4 Clinical characteristics of chronic ITP patients with IL-4 and IL-4Rα
IL-4 CC | IL-4 non-CC | IL-4Rα QQ | IL-4Rα non-QQ | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | (%) | N | (%) | P value | OR | 95% CI | N | (%) | N | (%) | P value | OR | 95% CI | |
No. of patients (%) | 17 | (13.5) | 109 | (86.5) | 88 | (69.8) | 38 | (30.2) | ||||||
Female patients, no. of cases (%) | 16 | (94.1) | 76 | (69.7) | 0.04 | 6.95 | 0.88–54.57 | 65 | (73.9) | 27 | (71.1) | 0.74 | 1.15 | 0.49–2.69 |
Age (years) at diagnosis, range (median) | 10.5–82.3 | (49.1) | 2.4–81.9 | (47.4) | 0.85 | 2.4–82.3 | (46.6) | 17.1–79.2 | (54.9) | 0.16 | ||||
Platelet count (×109/L) at diagnosis, mean ± SD | 24.5 | ± 22.4 | 30.3 | ± 24.7 | 0.36 | 29.8 | ± 24.8 | 28.9 | ± 23.9 | 0.84 | ||||
Mild thrombocytopenia, no. of cases (%) | 3 | (17.6) | 25 | (22.9) | 0.76 | 0.72 | 0.19–2.71 | 18 | (20.5) | 10 | (26.3) | 0.47 | 0.72 | 0.30–1.75 |
Moderate thrombocytopenia, no. of cases (%) | 3 | (17.6) | 25 | (22.9) | 0.76 | 0.72 | 0.19–2.71 | 22 | (25.0) | 6 | (15.8) | 0.35 | 1.78 | 0.66–4.82 |
Severe thrombocytopenia, no. of cases (%) | 6 | (35.3) | 34 | (31.2) | 0.78 | 1.20 | 0.41–3.52 | 26 | (29.5) | 14 | (36.8) | 0.42 | 0.72 | 0.32–1.60 |
Very severe thrombocytopenia, no. of cases (%) | 5 | (29.4) | 25 | (22.9) | 0.55 | 1.40 | 0.45–4.36 | 22 | (25.0) | 8 | (21.1) | 0.82 | 1.25 | 0.50–3.13 |
Minimum platelet count (×109⁄L), mean ± SD | 16.4 | ± 19.7 | 18.8 | ±17.8 | 0.61 | 17.5 | ± 17.4 | 20.8 | ± 19.4 | 0.35 | ||||
Bleeding tendency, no. of cases (%) | 11 | (64.7) | 69 | (63.3) | 1.00 | 1.06 | 0.37–3.09 | 55 | (62.5) | 25 | (65.8) | 0.73 | 0.87 | 0.39–1.92 |