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Table 4 Clinical characteristics of chronic ITP patients with IL-4 and IL-4Rα

From: The cytokine polymorphisms affecting Th1/Th2 increase the susceptibility to, and severity of, chronic ITP

  IL-4 CC IL-4 non-CC   IL-4Rα QQ IL-4Rα non-QQ  
N (%) N (%) P value OR 95% CI N (%) N (%) P value OR 95% CI
No. of patients (%) 17 (13.5) 109 (86.5)     88 (69.8) 38 (30.2)    
Female patients, no. of cases (%) 16 (94.1) 76 (69.7) 0.04 6.95 0.88–54.57 65 (73.9) 27 (71.1) 0.74 1.15 0.49–2.69
Age (years) at diagnosis, range (median) 10.5–82.3 (49.1) 2.4–81.9 (47.4) 0.85    2.4–82.3 (46.6) 17.1–79.2 (54.9) 0.16   
Platelet count (×109/L) at diagnosis, mean ± SD 24.5 ± 22.4 30.3 ± 24.7 0.36    29.8 ± 24.8 28.9 ± 23.9 0.84   
 Mild thrombocytopenia, no. of cases (%) 3 (17.6) 25 (22.9) 0.76 0.72 0.19–2.71 18 (20.5) 10 (26.3) 0.47 0.72 0.30–1.75
 Moderate thrombocytopenia, no. of cases (%) 3 (17.6) 25 (22.9) 0.76 0.72 0.19–2.71 22 (25.0) 6 (15.8) 0.35 1.78 0.66–4.82
 Severe thrombocytopenia, no. of cases (%) 6 (35.3) 34 (31.2) 0.78 1.20 0.41–3.52 26 (29.5) 14 (36.8) 0.42 0.72 0.32–1.60
 Very severe thrombocytopenia, no. of cases (%) 5 (29.4) 25 (22.9) 0.55 1.40 0.45–4.36 22 (25.0) 8 (21.1) 0.82 1.25 0.50–3.13
Minimum platelet count (×109⁄L), mean ± SD 16.4 ± 19.7 18.8 ±17.8 0.61    17.5 ± 17.4 20.8 ± 19.4 0.35   
Bleeding tendency, no. of cases (%) 11 (64.7) 69 (63.3) 1.00 1.06 0.37–3.09 55 (62.5) 25 (65.8) 0.73 0.87 0.39–1.92
  1. Mild thrombocytopenia: >50 × 109⁄L, moderate thrombocytopenia: 30 × 109–50 × 109⁄L, severe thrombocytopenia: 10 × 109–30 × 109⁄L, very severe thrombocytopenia: <10 × 109⁄L, minimum platelet count: minimum platelet count during the clinical course. ITP immune thrombocytopenia, IFN interferon, IL interleukin, OR odds ratio, CI confidence interval, SD standard deviation