IG and TR single chain fragment variable (scFv) sequence analysis: a new advanced functionality of IMGT/V-QUEST and IMGT/HighV-QUEST

Table 1 V-DOMAIN types analyzed by IMGT/V-QUEST

Receptor type	V-DOMAIN description			Locus name	Chain type (transcript or protein)
	Structure labels (IMGT/3Dstructure-DB)		Sequence labels (IMGT/LIGM-DB)	Locus name	Chain type (transcript or protein)
IG	VH		V-D-J-REGION	IGH	IG-Heavy
	VL^a	V-KAPPA	V-J-REGION	IGK	IG-Light-Kappa
		V-LAMBDA	V-J-REGION	IGL	IG-Light-Lambda
		V-IOTA^b	V-J-REGION	IGI	IG-Light-Iota
TR	V-ALPHA		V-J-REGION	TRA	TR-Alpha
	V-BETA		V-D-J-REGION	TRB	TR-Beta
	V-GAMMA		V-J-REGION	TRG	TR-Gamma
	V-DELTA		V-D-J-REGION	TRD	TR-Delta

^aV-RHO of the IG-Light-Rho (frog) and V-SIGMA of the Ig-Light-Sigma (Chondrichthyes and frog) are not shown but will be analyzed once the genomic germline V and J genes are sequenced and available in the IMGT/V-QUEST reference directory (Correspondence between chain types and C genes: IG and TR (all vertebrate species) [60])
^bV-IOTA is the VL of the IG-Light-Iota chain type (transcript or protein) of the Chondrichthyes and Actinopterygii (which include the Teleostei)

ISSN: 1471-2172