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Table 2 Effect of the re-immunization on VEGF-specific IgG, IgA and IgM antibodies or VEGF/VEGFR2 blockade

From: Characteristics of the specific humoral response in patients with advanced solid tumors after active immunotherapy with a VEGF vaccine, at different antigen doses and using two distinct adjuvants

Patient code IgG antibody titer IgA antibody titer IgM antibody titer VEGF/VEGFR2 blockade (%)
Pre-vaccination Re-immunization phase Pre-vaccination Re-immunization phase Pre-vaccination Re-immunization phase Pre-vaccination Re-immunization phase
Week
0
Sample A Sample B Week
0
Sample A Sample B Week
0
Sample A Sample
B
Week
0
Sample A Sample B
CH08 4 36 31 49 70 71 1183 1035 1101 11.2 18.7 11.9
JL12 26 700* 770* 49 93 56 298 528 604* 6.92 7.5 15.2*
CQ13 4 505* 582* 335 286 305 1655 2090 2198 10.8 29.4* 24.5*
CH19 4 232* 244* 49 59 68 1180 1462 1978 11.5 16.1 31.5*,#
CH20 1 374* 339* 110 94 62 963 629 675 4.6 12.1* 16.7*
CH27 8 207* 236* 268 472 319 1947 3422 3732 14.2 31.1* 29.9*
JL29 118 589* 795*,† 87 124 144 707 438 557 11.2 7.2 20.8#
JL30 1 17 17 69 72 75 886 663 688 14 19 18
CH33 133 1655* 1697* 111 676* 530* 2591 341140* 3859811*,† 8.7 27.2* 28.9*
JL42 41 40 56 70 73 96 1788 1374 2426 20 17 27#
CH45 0 4474* 3825* 48 80 84 543 4108* 4995*,† 7.6 27.4* 23*
JL49 463 947* 1110*,† 70 155* 125 509 1114* 1027* 16.3 27.5 34.1*
  1. Sample “A”: is the value for the sample taken just before the re-immunization; Sample “B”: is the value for the sample acquired 7–10 days after the taking of the sample “A”. [*]: sample meets the positivity criteria for specific-IgG (using formulas A and B), IgA or IgM antibodies (using formula A) or VEGF/VEGFR2 blockade (using formula D). (): sample meets the criterion of increase for antibody titer: sample “B” - sample “A” ≥ 1/100. (#): sample meets the criterion of increase for VEGF/VEGFR2 blockade: sample “B” - sample “A” ≥ 10%. Patients: CH08 (sample A taken at week 55; sample B taken at week 56); JL12 (sample A taken at week 53; sample B taken at week 54); CQ13 (sample A taken at week 48; sample B taken at week 49); CH19 (sample A taken at week 47; sample B taken at week 48); CH20 (sample A taken at week 50; sample B taken at week 51); CH27 (sample A taken at week 45; sample B taken at week 46); JL29 (sample A taken at week 48; sample B taken at week 49); JL30 (sample A taken at week 52; sample B taken at week 53); CH33 (sample A taken at week 48; sample B taken at week 49); JL42 (sample A taken at week 49; sample B taken at week 50); CH45 (sample A taken at week 48; sample B taken at week 49); JL49 (sample A taken at week 44; sample B taken at week 45)