Fig. 5

Neutralizing IL-10 at the time of immunization does not increase the incidence of diabetics in NOD mice. 6–8 weeks old adult female autoimmune prone NOD/Lt mice were divided into different groups. No treatment group (square), VLP immunization (Diamond), VLP immunization plus Normal Rat Serum (Down Triangle), VLP immunization plus anti-IL10R antibody (Cycle). Mice were either untreated or immunized twice with 50 μg of papillomvirus like particles with or without 500 μg of anti-IL10R antibody i.p. on day 0 and 14. The development of diabetes was monitored weekly. Results are shown of pooled results from two independent experiments