Table 2 Comparison of the cumulative incidence rates of complications in the first, second and third doses of the vaccination in children
Adverse events | Incidence (per 100 children) vaccine dose | P-value (1st and 2nd dose comparison) | P-value (2nd and 3rddose comparison) | ||
|---|---|---|---|---|---|
1st dose (2 months) N = 373 | 2nddose (4 months) N = 372 | 3rddose (6 months) N = 374 | |||
Swelling | 79(0.21) | 50(0.13) | 48(0.12) | 0.003 | 0.068 |
Redness | 50(0.13) | 30(0.08) | 43(0.11) | 0.026 | 0.679 |
Pain | 190(0.5) | 143(0.38) | 62(0.43) | 0.001 | 0.162 |
Mild fever | 45(0.12) | 33(0.08) | 63(0.16) | 0.068 | <0.001 |
High fever | 1(0.002) | 0(0) | 0(0) | 0.388 | NA |
Drowsiness | 83(0.22) | 72(0.19) | 70(0.18) | 0.310 | 0.725 |
Anorexia | 65(0.17) | 51(0.13) | 52(0.13) | 0.126 | 1 |
Restlessness | 35(0.06) | 115(0.3) | 119(0.31) | <0.001 | 0.766 |
Vomiting | 16(0.04) | 19(0.05) | 17(0.04) | 0.510 | 0.510 |
Long-term crying | 24(0.06) | 16(0.04) | 22(0.05) | 0.210 | 0.510 |
Encephalopathy | 0(0) | 0(0) | 0(0) | NA | NA |
Convulsion | 0(0) | 0(0) | 0(0) | NA | NA |
History of convulsion | 0(0) | 1(0.002) | 2(0.005) | 0.387 | 0.488 |
Family history of convulsion | 0(0) | 14(0.037) | 6(0.016) | <0.001 | 0.074 |