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Table 2 Comparison of the cumulative incidence rates of complications in the first, second and third doses of the vaccination in children

From: Adverse events following immunization with pentavalent vaccine: experiences of newly introduced vaccine in Iran

Adverse events Incidence (per 100 children) vaccine dose P-value (1st and 2nd dose comparison) P-value (2nd and 3rddose comparison)
1st dose (2 months)
N = 373
2nddose (4 months)
N = 372
3rddose (6 months)
N = 374
Swelling 79(0.21) 50(0.13) 48(0.12) 0.003 0.068
Redness 50(0.13) 30(0.08) 43(0.11) 0.026 0.679
Pain 190(0.5) 143(0.38) 62(0.43) 0.001 0.162
Mild fever 45(0.12) 33(0.08) 63(0.16) 0.068 <0.001
High fever 1(0.002) 0(0) 0(0) 0.388 NA
Drowsiness 83(0.22) 72(0.19) 70(0.18) 0.310 0.725
Anorexia 65(0.17) 51(0.13) 52(0.13) 0.126 1
Restlessness 35(0.06) 115(0.3) 119(0.31) <0.001 0.766
Vomiting 16(0.04) 19(0.05) 17(0.04) 0.510 0.510
Long-term crying 24(0.06) 16(0.04) 22(0.05) 0.210 0.510
Encephalopathy 0(0) 0(0) 0(0) NA NA
Convulsion 0(0) 0(0) 0(0) NA NA
History of convulsion 0(0) 1(0.002) 2(0.005) 0.387 0.488
Family history of convulsion 0(0) 14(0.037) 6(0.016) <0.001 0.074
  1. NA not applicable