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Fig. 4 | BMC Immunology

Fig. 4

From: Transcriptomic data from two primary cell models stimulating human monocytes suggest inhibition of oxidative phosphorylation and mitochondrial function by N. meningitidis which is partially up-regulated by IL-10

Fig. 4

Canonical pathways significantly enriched in human monocytes stimulated with patient plasma with IL-10 vs low LPS plasma. Significantly enriched canonical pathways were identified with a right-tailed Fisher’s Exact Test, that calculates a P-value determining the probability that each canonical pathway associated to the dataset was due to chance alone. The P-values were corrected for multiple testing using the Benjamini-Hochberg method for correcting the FDR, and a P-value of <0.05 was set as threshold for statistical significance. The z-score indicates predicted activation state of the canonical pathway. Blue color or lighter shades of blue indicate a negative z-score and down-regulation of the pathway, and orange color or lighter shades of orange indicate a positive z-score and up-regulation of the pathway. Ratio denotes the number of significantly expressed genes compared with the total number of genes associated with the canonical pathway

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