Table 7 Genes associated with mitochondrial function identified to be regulated by IL-10 in monocytes stimulated by N. meningitidis
Symbol | Entrez gene name | Location | Type(s) | Fold change1 | ||
|---|---|---|---|---|---|---|
Nm vs ctr | Nm + IL-10 vs ctr | Nm + IL-10 vs Nm | ||||
ACO2 | aconitase 2, mitochondrial | Cytoplasm | Enzyme | −1.66 | −1.33 | 1.25 |
ATP5A1 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle | Cytoplasm | Transporter | −1.83 | −1.34 | 1.37 |
ATP5H | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d | Cytoplasm | Enzyme | −1.50 | −1.18 | 1.27 |
BCL2 | B-cell CLL/lymphoma 2 | Cytoplasm | Transporter | NC | NC | −1.46 |
CASP3 | caspase 3, apoptosis-related cysteine peptidase | Cytoplasm | Peptidase | NC | 1.86 | 1.79 |
COX7C | cytochrome c oxidase subunit VIIc | Cytoplasm | Enzyme | −1.66 | NC | 1.45 |
CYB5A | cytochrome b5 type A (microsomal) | Cytoplasm | Enzyme | −1.69 | NC | 1.48 |
FURIN | furin (paired basic amino acid cleaving enzyme) | Cytoplasm | Peptidase | −2.47 | 1.42 | 3.51 |
NCSTN | nicastrin | Plasma Membrane | Peptidase | −1.41 | 1.17 | 1.21 |
NDUFA6 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14 kDa | Cytoplasm | Enzyme | −2.00 | −1.53 | 1.31 |
NDUFA9 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39 kDa | Cytoplasm | Enzyme | 1.28 | 3.10 | 2.43 |
NDUFA10 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42 kDa | Cytoplasm | Transporter | −1.38 | −1.14 | 1.22 |
NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8 kDa | Cytoplasm | Enzyme | −2.26 | −1.56 | 1.45 |
NDUFB5 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16 kDa | Cytoplasm | Enzyme | −1.48 | NC | 1.37 |
NDUFS2 | NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49 kDa (NADH-coenzyme Q reductase) | Cytoplasm | Enzyme | −2.04 | NC | 1.92 |
NDUFS6 | NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13 kDa (NADH-coenzyme Q reductase) | Cytoplasm | Enzyme | −1.74 | −1.42 | 1.22 |
NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24 kDa | Cytoplasm | Enzyme | NC | −1.61 | −1.44 |
PRDX3 | peroxiredoxin 3 | Cytoplasm | Enzyme | −1.63 | NC | 1.47 |
SDHB | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | Cytoplasm | Enzyme | −1.91 | −1.41 | 1.35 |
TRAK1 | trafficking protein, kinesin binding 1 | Nucleus | Other | −1.29 | NC | 1.25 |
UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | Cytoplasm | Transporter | −2.07 | −1.49 | 1.39 |
UQCR10 | ubiquinol-cytochrome c reductase, complex III subunit X | Cytoplasm | Enzyme | −1.75 | −1.38 | 1.26 |
VPS9D1 | VPS9 domain containing 1 | Other | Transporter | NC | NC | 1.86 |