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Fig. 8 | BMC Immunology

Fig. 8

From: C-reactive protein (CRP) but not the related pentraxins serum amyloid P and PTX3 inhibits the proliferation and induces apoptosis of the leukemia cell line Mono Mac 6

Fig. 8

CRP regulates phospho-ERK and total PTEN levels. Mono Mac 6 cells were incubated in the presence or absence of 75 μg/ ml CRP for 24 h. Cells were then lysed and equal numbers of cells were analyzed by western blotting for a) phosphorylated ERK, b) PTEN, or c) actin as a loading control. Blots are representative of 3 independent experiments. The positions of molecular mass standards in kDa are at left. Staining for d) pERK at 24 h, and e) total PTEN at 24 h was quantified by densitometry. Values are mean ± SEM, n = 3 independent experiments. ** indicates p < 0.01 (t-test)

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