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Fig. 9 | BMC Immunology

Fig. 9

From: C-reactive protein (CRP) but not the related pentraxins serum amyloid P and PTX3 inhibits the proliferation and induces apoptosis of the leukemia cell line Mono Mac 6

Fig. 9

CRP inhibits the proliferation of and increases apoptosis of Mono Mac 6 cells. a-c Mono Mac 6 cells were incubated for 48 h in the presence or absence of the indicated concentrations of CRP. a Cells were then stained for active caspase 3 and Ki-67. Images are representative of 3 independent experiments. Bar is 100 μm. b Quantification of caspase 3 and Ki-67 staining. Values are mean ± SEM, n = 3 independent experiments. ** indicates p < 0.01 (t test). c Flow cytometry analysis of Ki67 and active caspase 3 expression in Mono Mac 6 cells. Values are mean ± SEM, n = 3 independent experiments. * p < 0.05, ** p < 0.01 (t test). d Mono Mac 6 cells were incubated in the presence or absence of 75 μg/ml CRP for the indicated times. Cells were then lysed and western blots of the lysates were stained for active caspase 3. The position of molecular mass markers in kDa is at left. Image is representative of 3 independent experiments

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