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Fig. 2 | BMC Immunology

Fig. 2

From: Helios + Regulatory T cell frequencies are correlated with control of viral replication and recovery of absolute CD4 T cells counts in early HIV-1 infection

Fig. 2

Proportions of CD8 T cells co-expressing the activation markers and chemokine receptors. PBMC from 15 HIV uninfected individuals and 14 individuals early infected by HIV-1, were isolated and manipulated as described in methods section. These PBMC, were stained with monoclonal antibodies and analyzed by polychromatic flow cytometry. Viral loads and frequency of antibodies reactive to HIV-1 proteins was determined using plasma samples and serum, respectively, as described on methods section. a Median and interquartile range of proportions of CD8 T cells co-expressing the activation markers CD38 and HLA-DR between uninfected and HIV early infected groups. Each point represents an individual. Unpaired Mann-Whitney test p-values, comparing medians from HIV uninfected group and individuals with HIV early infection, are indicated on each figure. b-c Correlation analysis between the immune activation of CD8 T cells with the viral loads and frequency of antibodies reactive to HIV-1 proteins in HIV-1 early infected subjects. Spearman correlation r and p-values are indicated on each figure. d-e Median and IQR of proportions of CD8 T cells expressing the chemokine receptors, CCR5 and CXCR4. Each point represents an individual. Unpaired Mann-Whitney test p-values, comparing medians from HIV uninfected group and individuals with HIV early infection, are indicated on each figure

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