Fig. 3

Analysis of the major genes correlated with the antibody response against Hib. a Gene classification. The differentially expressed genes (437 in the Hib conjugate vaccine group versus the CPS group and 596 in the Hib conjugate vaccine group versus the TT group) were classified into groups. The figure shows the percent (y-axis) of each clarification of gene (the intersection) to the differentially expressed genes (437 in the Hib conjugate vaccine group versus the CPS group and 596 in the Hib conjugate vaccine group versus the TT group). Multifunctional genes were put into different classes. The percent of differentially classified genes was showed above the column. b Global view of the modulation of gene expression in PBMCs obtained from immunized macaques at 1, 2 and 3 months post-inoculation. The individual sets, which are indicated by different colors, show the numbers of significantly modulated genes at each time point. A total of 39 genes (including a specific set of 8 genes) differed between the Hib vaccine and the CPS antigen groups during the entire immunization period. A total of 49 genes (including the same set of 8 genes) differed between the Hib vaccine and the carrier TT groups during the entire immunization period. Thus, a total of 8 genes (shown in red) differed between the vaccine group (Hib vaccine) and the control groups (CPS and TT) during the whole immunization period