Distribution of M1 and M2 macrophages in tumor islets and stroma in relation to prognosis of non-small cell lung cancer

Table 2 Association between total M1 and M2 macrophages and clinicopathological characteristics

Characteristic	M1 macrophages	P	M2 macrophages	P
Gender:
Female	99.5 (54–147)	NS	101.5 (53–136)	NS
Male	96 (61–147)	NS	117 (45–186)	NS
Age, years:
< 65	101 (61–147)	NS	117 (45–145)	NS
≥ 65	96 (54–147)	NS	112 (53–186)	NS
Smoking status:
Smokers	98.5 (61–147)	< 0.05*	117 (45–186)	< 0.05*
Non-smokers	87.5 (54–147)	< 0.05*	101.5 (53–122)	< 0.05*
Histological NSCLC type:
Adenocarcinoma	94.5 (54–147)	NS	111 (53–144)	NS
Squamous cell carcinoma	98 (62–136)		118 (45–186)
Other	94 (61–147)		117 (87–121)
Stage:
IA-IB	95 (62–128)	NS	119 (64–186)	NS
IIA-IIB	95.5 (54–136)		112 (68–150)
IIIA-IIIB	104 (61–147)		117 (45–145)
pT status:
pT1a-2b	96 (54–147)	NS	115 (64–186)	NS
pT3–4	97.5 (61–147)	NS	117 (45–137)	NS
Lymph node status:
Negative (N0)	95 (54–133)	NS	116 (64–186)	NS
Positive (N1-N3)	99 (61–147)	NS	115 (45–150)	NS
Differentiation:
Poor	97 (54–133)	NS	118 (53–186)	< 0.05*
Well-moderate	95 (61–147)		108 (45–137)
COPD:
Present	103 (73–147)	NS	116 (74–186)	NS
Absent	94.5 (54–147)		115 (45–145)	NS

The number of macrophages represents median (range) per ten high-power fields in tumor tissue (the sum of macrophages in tumor islets and stroma)
NS not significant
*P < 0.05, Mann-Whitney test

ISSN: 1471-2172