Table 4 Univariate analysis of factors associated with overall survival
Variables | Univariate analysis | ||
|---|---|---|---|
HR | 95% CI | P | |
Age (< 65 vs. ≥65) | 1.47 | 0.68–3.17 | NS |
Gender (female vs. male) | 0.74 | 0.29–1.84 | NS |
Stage (I vs. II vs. III) | 1.64 | 1.00–2.69 | 0.049 |
Histology (adeno vs. other) | 1.50 | 0.69–3.27 | NS |
Lymph node status (negative vs. positive) | 2.09 | 0.95–4.60 | NS |
pT status (pT1a-2b vs. pT3–4) | 2.65 | 1.25–5.62 | 0.011 |
Differentiation (poor vs. well-moderate) | 0.80 | 0.37–1.75 | NS |
Smoking (smokers vs. nonsmokers) | 0.48 | 0.18–1.23 | NS |
COPD (present vs. absent) | 1.17 | 0.54–2.55 | NS |
M1 macrophages in islets (high vs. low) | 2.83 | 1.20–6.68 | 0.017 |
M1 macrophages in stroma (high vs. low) | 1.91 | 0.86–4.25 | NS |
Total M1 macrophages (high vs. low) | 1.43 | 0.63–3.21 | NS |
M2 macrophages in islets (high vs. low) | 1.43 | 0.66–1.43 | NS |
M2 macrophages in stroma (high vs. low) | 1.00 | 0.73–1.37 | NS |
Total M2 macrophages (high vs. low) | 0.31 | 0.13–0.75 | 0.009 |
IL-10 | 0.74 | 0.35–1.55 | NS |
TNF-α | 1.16 | 0.55–2.45 | NS |
IFN-γ | 0.67 | 0.31–1.43 | NS |