Table 1 Preparation of the nine vaccine formulations (test group) and control groups
From: Down selecting adjuvanted vaccine formulations: a comparative method for harmonized evaluation
Formulations | Test group | Adjuvant-only control group | |
|---|---|---|---|
Adjuvant suspension | Antigen solution | ||
AlOH | 85 μL AlOH + 165 μL SFI | 10 μg AMA1 in 250 μL SFI | 250 μL adjuvant suspension + 250 μL PBS |
50 μg HBsAg in 250 μL SFI | |||
100 μg Ag85A in 250 μL SFI | |||
HBsAg | 250 μL SWE | 40 μg/mL AMA1 in 250 μL PBS | 250 μL adjuvant suspension + 250 μL PBS |
200 μg/mL HBsAg in 250 μL PBS | |||
400 μg/mL Ag85A in 250 μL PBS | |||
Ag85A | 100 μL QS21 (1 mg/mL) + 100 μL DOPC:Chol + 50 μL PBS | 10 μg AMA1 in 250 μL PBS | 200 μL adjuvant suspension + 300 μL PBS |
50 μg HBsAg in 250 μL PBS | |||
100 μg Ag85A in 250 μL PBS | |||