Table 1 HLA class I binding of CTL epitopes associated with previously defined diabetes-associated proteins
Source protein | Epitope sequence | Target assay | IC50 nM |
|---|---|---|---|
AN1-type zinc finger protein 5 | SASVQRADTSL | B*07:02 | 11 |
Bruton agammaglobulinemia tyrosine kinase | CLCLLNPQGT | A*02:01 | – |
HLASEKVYAI | A*02:01 | 4064 | |
KLANIQCLCL | A*02:01 | 97 | |
KLANIQCPCL | A*02:01 | 121 | |
LASEKVYAI | A*02:01 | 6926 | |
SLTAISTTL | A*02:01 | 242 | |
SLTTISTTL | A*02:01 | 237 | |
YIPSCTVVGM | A*02:01 | 9506 | |
Fms-related tyrosine kinase 3 | KVLHELFGMDI | A*02:01 | 11 |
VLHELFGMDI | A*02:01 | 287 | |
Fms-related tyrosine kinase 3 ligand | ALARGAGTVPL | A*02:01 | 29 |
SMPQGTFPV | A*02:01 | 631 | |
Glial fibrillary acidic protein isoform 2 | NLAQDLATV | A*02:01 | 67 |
QLARQQVHV | A*02:01 | – | |
SLEEEIRFL | A*02:01 | 472 | |
Glutamate decarboxylase 2 | RFKMFPEVK | A*11:01 | 18,296 |
MFPEVKEKG | A*11:01 | – | |
SPGSGFWSF | B*07:02 | 1173 | |
TSEHSHFSL | B*35:01 | – | |
ELAEYLYNI | A*02:01 | 637 | |
FLQDVMNIL | A*02:01 | 70 | |
ILMHCQTTL | A*02:01 | 478 | |
LLQEYNWEL | A*02:01 | 35 | |
RMMEYGTTMV | A*02:01 | 709 | |
VMNILLQYV | A*02:01 | 2024 | |
VMNILLQYVV | A*02:01 | 2308 | |
ACDGERPTL | B*07:02 | 28,719 | |
AHVDKCLEL | B*07:02 | – | |
APVIKARMM | B*07:02 | 18,197 | |
HPRYFNQLST | B*07:02 | 1252 | |
IPSDLERRIL | B*07:02 | 3858 | |
Heat shock 70 kDa protein 1 | LLDVAPLSL | A*02:01 | 51 |
LLLLDVAPL | A*02:01 | 10 | |
LMGDKSENV | A*02:01 | 7374 | |
Heat shock 70 kDa protein 6 | FIQVYEVERA | A*02:01 | 7024 |
FMTSSWWGA | A*02:01 | 378 | |
FMTSSWWRA | A*02:01 | 101 | |
FMTSSWWRAPL | A*02:01 | 84 | |
GIPPAPHGV | A*02:01 | 219 | |
GLLQVHHSCPL | A*02:01 | 5.8 | |
GVFIQVYEV | A*02:01 | 460 | |
KCQEVLAWL | A*02:01 | – | |
LLGRFELIGI | A*02:01 | 233 | |
LLHVHHSCPL | A*02:01 | 7839 | |
LLQVHHSCPL | A*02:01 | 3087 | |
NLLGRFELI | A*02:01 | 764 | |
NLLGRFELIGI | A*02:01 | 1.8 | |
SLASLLPHV | A*02:01 | 9.1 | |
SMCRFSPLTL | A*02:01 | 1149 | |
SVASLLPHV | A*02:01 | 1758 | |
VLNSLASLL | A*02:01 | 4968 | |
VLNSVASLL | A*02:01 | 1143 | |
VLVEGSTRI | A*02:01 | 17,161 | |
Heat shock 70 kDa protein 6 variant | SLFEGVDFYT | A*02:01 | 51 |
Heat shock 70 kDa protein 1A variant | GIPPAPRGV | A*02:01 | 1226 |
LIFDLGGGT | A*02:01 | 5416 | |
Heat shock protein HSP 90-beta | ILDKKVEKV | A*02:01 | 11,237 |
Insulin | WGPDPAAA | A*02:01 | – |
GIVEQCCTSI | A*02:01 | 7446 | |
LCGSHLVEAL | A*02:01 | – | |
SHLVEALYLV | A*02:01 | 2153 | |
ALWGPDPAAA | A*02:01 | 1008 | |
HLVEALYLV | A*02:01 | 134 | |
SLYQLENYC | A*02:01 | 16,923 | |
RLLPLLALL | A*02:01 | 145 | |
A*24:02 | 10,212 | ||
VCGERGFFYT | A*01:01 | – | |
A*02:01 | – | ||
B*08:01 | – | ||
B*18:01 | 626 | ||
ALWMRLLPLL | A*02:01 | 190 | |
A*24:02 | 6181 | ||
B*08:01 | 33 | ||
ALWMRLLPL | A*02:01 | 218 | |
B*08:01 | 107 | ||
GSHLVEALY | A*01:01 | 30,269 | |
LVCGERGFFY | A*01:01 | – | |
A*03:01 | 27,363 | ||
A*11:01 | 27,207 | ||
GERGFFYT | A*01:01 | – | |
B*08:01 | 1377 | ||
LALWGPDPAA | A*02:01 | 30,300 | |
RLLPLLALLAL | A*02:01 | 109 | |
HLCGSHLVEA | A*02:01 | 7536 | |
SLQKRGIVEQ | A*02:01 | – | |
LYLVCGERGF | A*24:02 | 5255 | |
LWMRLLPLL | A*24:02 | 545 | |
ALWGPDPAAAF | A*01:01 | – | |
A*24:02 | 15,101 | ||
ERGFFYTPK | A*03:01 | – | |
PLALEGSLQK | A*03:01 | – | |
PLLALLALWG | A*03:01 | – | |
ALYLVCGER | A*03:01 | 2793 | |
A*11:01 | 28,341 | ||
SLQPLALEG | A*02:01 | – | |
A*03:01 | – | ||
LPLLALLAL | B*07:02 | 610 | |
B*35:01 | 12,300 | ||
B*51:01 | 1164 | ||
WMRLLPLLAL | B*07:02 | 2359 | |
FYTPKTRRE | B*08:01 | 13,033 | |
Islet amyloid polypeptide precursor | FLIVLSVAL | A*02:01 | 26 |
KLQVFLIVL | A*02:01 | 1372 | |
Islet-specific glucose-6-phosphatase | FLWSVFMLI | A*02:01 | 26 |
Islet-specific glucose-6-phosphatase isoform 1 | FLWSVFWLI | A*02:01 | 55 |
RLLCALTSL | A*02:01 | 91 | |
LNIDLLWSV | A*02:01 | 684 | |
VLFGLGFAI | A*02:01 | 149 | |
NLFLFLFAV | A*02:01 | 1228 | |
YLLLRVLNI | A*02:01 | 57 | |
FLFAVGFYL | A*02:01 | 1.1 | |
Protein tyrosine phosphatase | LLPPLLEHL | A*02:01 | 444 |
SLAAGVKLL | A*02:01 | 3686 | |
SLSPLQAEL | A*02:01 | 101 | |
ALTAVAEEV | A*02:01 | 1306 | |
SLYHVYEVNL | A*02:01 | 209 | |
TIADFWQMV | A*02:01 | 4693 | |
VIVMLTPLV | A*02:01 | 2117 | |
MVWESGCTV | A*02:01 | 126 | |
Tyrosine-protein kinase BTK | LASEKVYTI | A*02:01 | 1254 |
Tyrosine-protein kinase Lyn isoform B | LMFWSPSHSCA | A*02:01 | 143 |
RLQREWHTL | A*02:01 | 1230 | |
Tyrosine-protein phosphatase non-receptor type 11 | RLGPVARTRV | A*02:01 | 581 |
STVASRLGPV | A*02:01 | 25,069 | |
STVASWLGPV | A*02:01 | 9227 | |
TLSSRVCCRT | A*02:01 | 2784 | |
TVASRLGPV | A*02:01 | 7695 | |
Zinc finger protein 36, C3H1 type-like 2 | GLPAGAAAQA | A*02:01 | 530 |
HLSYHRLLPL | A*02:01 | 4259 | |
HLSYHWLLPL | A*02:01 | 3817 | |
RLLPLWAAL | A*02:01 | 52 | |
RLLPLWAALPL | A*02:01 | 5.4 | |
RLRPLCCTA | A*02:01 | 8234 | |
WLLPLWAAL | A*02:01 | 4.2 | |
WLLPLWAALPL | A*02:01 | 3.2 | |
Zinc transporter 8 isoform a | ALGDLFQSI | A*02:01 | 76 |
AVAANIVLTV | A*02:01 | 575 | |
FLLSLFSLWL | A*02:01 | 16 | |
HIAGSLAVV | A*02:01 | 216 | |
ILAVDGVLSV | A*02:01 | 2.2 | |
ILKDFSILL | A*02:01 | 39 | |
ILVLASTITI | A*02:01 | 675 | |
IQATVMIIV | A*02:01 | 9043 | |
KMYAFTLES | A*02:01 | 880 | |
RLLYPDYQI | A*02:01 | 124 | |
SISVLISAL | A*02:01 | 1555 | |
TMHSLTIQM | A*02:01 | 104 | |
VAANIVLTV | A*02:01 | 320 | |
VVTGVLVYL | A*02:01 | 9.0 | |
LLIDLTSFL | A*02:01 | 8.1 | |
LLSILCIWV | A*02:01 | 734 | |
LLSLFSLWL | A*02:01 | 152 |