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Table 3 Insulin-derived epitope-HLA-A*02 binding was improved by PTMs

From: Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications

    

Sequence

 

A*02:01 binding

Fold increase

Set

Start

Segment

Len

WT

Modified

Modification

WT

Modified

 

Improved

A*02 epitopes

2

Leader

9

ALWMRLLPL

ALWMULLPL

Citrullination

218

28

7.83

  

10

ALWMRLLPLL

ALWMULLPLL

Citrullination

190

69

2.76

33

B chain

10

SHLVEALYLV

SHLVEALJLV

Chlorination

2153

1066

2.02

34

B chain

9

HLVEALYLV

HLVEALJLV

Chlorination

134

55

2.43

Other improved peptides

1

Leader

9

MALWMRLLP

MALWMULLP

Citrullination

4539

2117

2.14

1

Leader

10

MALWMRLLPL

MALWMULLPL

Citrullination

1255

262

4.79

3

Leader

10

LWMRLLPLLA

LWMULLPLLA

Citrullination

406

61

6.62

4

Leader

10

WMRLLPLLAL

WMULLPLLAL

Citrullination

654

310

2.11

28

B chain

9

QHLCGSHLV

EHLCGSHLV

Deamidation

7237

> 5

31

B chain

10

CGSHLVEALY

BGSHLVEALY

Oxidation of C

33,691

8043

4.19

37

B chain

10

EALYLVCGER

EALYLVCGEU

Citrullination

10,069

3100

3.25

38

B chain

10

ALYLVCGERG

ALJLVCGERG

Chlorination

8784

2734

3.21

39

B chain

9

LYLVCGERG

LYLVCGEUG

Citrullination

28,006

12,493

2.24

40

B chain

9

YLVCGERGF

JLVCGERGF

Chlorination

6742

3163

2.13

    

YLVBGERGY

Pan oxidation

6742

3244

2.08

45

B chain

10

ERGFFYTPKT

ERGYYYTPKT

Pan oxidation

5730

> 7

46

B chain

9

RGFFYTPKT

RGYYYTPKT

Pan oxidation

8805

> 4

80

C peptide

10

LALEGSLQKR

LALEGSLQKU

Citrullination

16,354

> 2

  1. A dash indicates IC50 > 40,000 nM