Sequence | A*02:01 binding | Fold increase | |||||||
---|---|---|---|---|---|---|---|---|---|
Set | Start | Segment | Len | WT | Modified | Modification | WT | Modified | |
Improved A*02 epitopes | 2 | Leader | 9 | ALWMRLLPL | ALWMULLPL | Citrullination | 218 | 28 | 7.83 |
10 | ALWMRLLPLL | ALWMULLPLL | Citrullination | 190 | 69 | 2.76 | |||
33 | B chain | 10 | SHLVEALYLV | SHLVEALJLV | Chlorination | 2153 | 1066 | 2.02 | |
34 | B chain | 9 | HLVEALYLV | HLVEALJLV | Chlorination | 134 | 55 | 2.43 | |
Other improved peptides | 1 | Leader | 9 | MALWMRLLP | MALWMULLP | Citrullination | 4539 | 2117 | 2.14 |
1 | Leader | 10 | MALWMRLLPL | MALWMULLPL | Citrullination | 1255 | 262 | 4.79 | |
3 | Leader | 10 | LWMRLLPLLA | LWMULLPLLA | Citrullination | 406 | 61 | 6.62 | |
4 | Leader | 10 | WMRLLPLLAL | WMULLPLLAL | Citrullination | 654 | 310 | 2.11 | |
28 | B chain | 9 | QHLCGSHLV | EHLCGSHLV | Deamidation | – | 7237 | > 5 | |
31 | B chain | 10 | CGSHLVEALY | BGSHLVEALY | Oxidation of C | 33,691 | 8043 | 4.19 | |
37 | B chain | 10 | EALYLVCGER | EALYLVCGEU | Citrullination | 10,069 | 3100 | 3.25 | |
38 | B chain | 10 | ALYLVCGERG | ALJLVCGERG | Chlorination | 8784 | 2734 | 3.21 | |
39 | B chain | 9 | LYLVCGERG | LYLVCGEUG | Citrullination | 28,006 | 12,493 | 2.24 | |
40 | B chain | 9 | YLVCGERGF | JLVCGERGF | Chlorination | 6742 | 3163 | 2.13 | |
YLVBGERGY | Pan oxidation | 6742 | 3244 | 2.08 | |||||
45 | B chain | 10 | ERGFFYTPKT | ERGYYYTPKT | Pan oxidation | – | 5730 | > 7 | |
46 | B chain | 9 | RGFFYTPKT | RGYYYTPKT | Pan oxidation | – | 8805 | > 4 | |
80 | C peptide | 10 | LALEGSLQKR | LALEGSLQKU | Citrullination | – | 16,354 | > 2 |