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Fig. 4 | BMC Immunology

Fig. 4

From: Neutrophils in primary gastric tumors are correlated with neutrophil infiltration in tumor-draining lymph nodes and the systemic inflammatory response

Fig. 4

Immunohistochemical staining of CXCR2+neutrophils with anti-CXCR2 antibody (Abcam, Tokyo, Japan) in primary tumor and lymph nodes. a: High expression of CXCR2+neutrophils in lymph node. (× 400) Scale bar 0.1 mm. b: Low expression of CXCR2+neutrophils in lymph node. (× 400) Scale bar 0.1 mm. c,d: The same section of primary tumors were immunostained with anti-CD15 antibody and anti-CXCR2 antibody, and its positional relationship was examined. CD15+TAN and CXCR2+neutrophis were similarly expressed at the position. c: Infiltration of CD15+TANs around tumor cell in primary tumor. (× 400) Scale bar 0.1 mm D: CXCR2+neutrophils infiltrated into the same position as CD15 + TAN. (× 400) Scale bar 0.1 mm e, f: Comparative study on the number of CXCR2+neutrophils in each group. The number of CXCR2+neutorophils were significantly higher in high CD15+TANs groups than low CD15+TANs groups in both primary tumor and lymph nodes. (primary tumor: P < 0.001, lymph node: P < 0.001) *p < 0.05

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