TY - JOUR AU - Ananthakrishnan, A. N. AU - Bernstein, C. N. AU - Iliopoulos, D. AU - Macpherson, A. AU - Neurath, M. F. AU - Ali, R. A. R. PY - 2017 DA - 2017// TI - Environmental triggers in IBD: a review of progress and evidence JO - Nat Rev Gastroenterol Hepatol VL - 15 UR - https://doi.org/10.1038/nrgastro.2017.136 DO - 10.1038/nrgastro.2017.136 ID - Ananthakrishnan2017 ER - TY - JOUR AU - Neurath, M. F. PY - 2014 DA - 2014// TI - Cytokines in inflammatory bowel disease JO - Nat Rev Immunol VL - 14 UR - https://doi.org/10.1038/nri3661 DO - 10.1038/nri3661 ID - Neurath2014 ER - TY - JOUR AU - Hindryckx, P. AU - Jairath, V. AU - D’Haens, G. PY - 2016 DA - 2016// TI - Acute severe ulcerative colitis: from pathophysiology to clinical management JO - Nat Rev Gastroenterol Hepatol VL - 13 UR - https://doi.org/10.1038/nrgastro.2016.116 DO - 10.1038/nrgastro.2016.116 ID - Hindryckx2016 ER - TY - JOUR AU - Conrad, K. AU - Roggenbuck, D. AU - Laass, M. W. PY - 2014 DA - 2014// TI - Diagnosis and classification of ulcerative colitis JO - Autoimmun Rev VL - 13 UR - https://doi.org/10.1016/j.autrev.2014.01.028 DO - 10.1016/j.autrev.2014.01.028 ID - Conrad2014 ER - TY - STD TI - Jena G, Trivedi PP, Sandala B. Oxidative stress in ulcerative colitis: an old concept but a new concern. Free Radic res [internet]. Taylor & Francis; 2012 [cited 2018 Apr 12];46:1339–45. Available from: http://www.tandfonline.com/doi/full/10.3109/10715762.2012.717692 UR - http://www.tandfonline.com/doi/full/10.3109/10715762.2012.717692 ID - ref5 ER - TY - JOUR AU - Putoczki, T. L. AU - Thiem, S. AU - Loving, A. AU - Busuttil, R. A. AU - Wilson, N. J. AU - Ziegler, P. K. PY - 2013 DA - 2013// TI - Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically JO - Cancer Cell VL - 24 UR - https://doi.org/10.1016/j.ccr.2013.06.017 DO - 10.1016/j.ccr.2013.06.017 ID - Putoczki2013 ER - TY - JOUR AU - Ratsimandresy, R. A. AU - Indramohan, M. AU - Dorfleutner, A. AU - Stehlik, C. PY - 2017 DA - 2017// TI - The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway JO - Cell Mol Immunol VL - 14 UR - https://doi.org/10.1038/cmi.2016.35 DO - 10.1038/cmi.2016.35 ID - Ratsimandresy2017 ER - TY - STD TI - Wang Z, Li S, Cao Y, Tian X, Zeng R, Liao D-F, et al. Oxidative stress and carbonyl lesions in ulcerative colitis and associated colorectal cancer. Oxid Med Cell Longev [Internet]. Hindawi Limited; 2015 [cited 2018 Mar 4];2016:9875298. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26823956 UR - http://www.ncbi.nlm.nih.gov/pubmed/26823956 ID - ref8 ER - TY - JOUR AU - Bakiri, L. AU - Wagner, E. F. PY - 2016 DA - 2016// TI - News and views on EMT Fra-1 controls EMT in mammary epithelial cells JO - Mol Cell Oncol VL - 3 UR - https://doi.org/10.4161/23723556.2014.990307 DO - 10.4161/23723556.2014.990307 ID - Bakiri2016 ER - TY - JOUR AU - Hasselblatt, P. AU - Gresh, L. AU - Kudo, H. AU - Guinea-Viniegra, J. AU - Wagner, E. F. PY - 2008 DA - 2008// TI - The role of the transcription factor AP-1 in colitis-associated and β-catenin-dependent intestinal tumorigenesis in mice JO - Oncogene VL - 27 UR - https://doi.org/10.1038/onc.2008.211 DO - 10.1038/onc.2008.211 ID - Hasselblatt2008 ER - TY - JOUR AU - Liu, H. AU - Ren, G. AU - Wang, T. AU - Chen, Y. AU - Gong, C. AU - Bai, Y. PY - 2015 DA - 2015// TI - Aberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal cancer aggressiveness through epithelial–mesenchymal transition JO - Carcinogenesis VL - 36 UR - https://doi.org/10.1093/carcin/bgv017 DO - 10.1093/carcin/bgv017 ID - Liu2015 ER - TY - JOUR AU - Moriyama, I. AU - Ishihara, S. AU - Rumi, M. A. K. AU - Aziz, M. D. M. AU - Mishima, Y. AU - Oshima, N. PY - 2008 DA - 2008// TI - Decoy oligodeoxynucleotide targeting activator protein-1 (AP-1) attenuates intestinal inflammation in murine experimental colitis JO - Lab Investig VL - 88 UR - https://doi.org/10.1038/labinvest.2008.38 DO - 10.1038/labinvest.2008.38 ID - Moriyama2008 ER - TY - JOUR AU - Nishina, T. AU - Komazawa-Sakon, S. AU - Yanaka, S. AU - Piao, X. AU - Zheng, D. -. M. AU - Piao, J. -. H. PY - 2012 DA - 2012// TI - Interleukin-11 links oxidative stress and compensatory proliferation JO - Sci Signal VL - 5 UR - https://doi.org/10.1126/scisignal.2002056 DO - 10.1126/scisignal.2002056 ID - Nishina2012 ER - TY - JOUR AU - Nishina, T. AU - Deguchi, Y. AU - Miura, R. AU - Yamazaki, S. AU - Shinkai, Y. AU - Kojima, Y. PY - 2017 DA - 2017// TI - Critical contribution of nuclear factor erythroid 2-related factor 2 (NRF2) to electrophile-induced Interleukin-11 production JO - J Biol Chem VL - 292 UR - https://doi.org/10.1074/jbc.M116.744755 DO - 10.1074/jbc.M116.744755 ID - Nishina2017 ER - TY - JOUR AU - Ropeleski, M. J. AU - Tang, J. AU - Walsh-Reitz, M. M. AU - Musch, M. W. AU - Chang, E. B. PY - 2003 DA - 2003// TI - Interleukin-11-induced heat shock protein 25 confers intestinal epithelial-specific cytoprotection from oxidant stress JO - Gastroenterology VL - 124 UR - https://doi.org/10.1016/S0016-5085(03)00282-8 DO - 10.1016/S0016-5085(03)00282-8 ID - Ropeleski2003 ER - TY - JOUR AU - Bollrath, J. AU - Phesse, T. J. AU - von Burstin, V. A. AU - Putoczki, T. AU - Bennecke, M. AU - Bateman, T. PY - 2009 DA - 2009// TI - gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis JO - Cancer Cell VL - 15 UR - https://doi.org/10.1016/j.ccr.2009.01.002 DO - 10.1016/j.ccr.2009.01.002 ID - Bollrath2009 ER - TY - JOUR AU - Gibson, D. L. AU - Montero, M. AU - Ropeleski, M. J. AU - Bergstrom, K. S. B. AU - Ma, C. AU - Ghosh, S. PY - 2010 DA - 2010// TI - Interleukin-11 reduces TLR4-induced colitis in TLR2-deficient mice and restores intestinal STAT3 signaling JO - Gastroenterology VL - 139 UR - https://doi.org/10.1053/j.gastro.2010.06.057 DO - 10.1053/j.gastro.2010.06.057 ID - Gibson2010 ER - TY - STD TI - Schroeder KW, Tremaine WJ, Ilstrup DM. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. N Engl J Med [Internet]. 1987 [cited 2018 Mar 6];317:1625–9. Available from: http://www.nejm.org/doi/abs/10.1056/NEJM198712243172603 UR - http://www.nejm.org/doi/abs/10.1056/NEJM198712243172603 ID - ref18 ER - TY - STD TI - Satsangi J, Silverberg MS, Vermeire S, Colombel JfJ-F. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut [Internet]. 2006 [cited 2018 Mar 6];55:749–53. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16698746 UR - http://www.ncbi.nlm.nih.gov/pubmed/16698746 ID - ref19 ER - TY - STD TI - ELISA sample preparation guide | Abcam [Internet]. [cited 2018 Feb 26]. Available from: http://www.abcam.com/protocols/elisa-sample-preparation-guide-1 UR - http://www.abcam.com/protocols/elisa-sample-preparation-guide-1 ID - ref20 ER - TY - JOUR AU - Verma, R. AU - Verma, N. AU - Paul, J. PY - 2013 DA - 2013// TI - Expression of inflammatory genes in the colon of ulcerative colitis patients varies with activity both at the mRNA and protein level JO - Eur Cytokine Netw VL - 24 ID - Verma2013 ER - TY - JOUR AU - Zhu, H. AU - Li, Y. R. PY - 2012 DA - 2012// TI - Oxidative stress and redox signaling mechanisms of inflammatory bowel disease: updated experimental and clinical evidence JO - Exp Biol Med VL - 237 UR - https://doi.org/10.1258/ebm.2011.011358 DO - 10.1258/ebm.2011.011358 ID - Zhu2012 ER - TY - STD TI - Klein W, Tromm A, Griga T, Fricke H, Folwaczny C, Hocke M, et al. A polymorphism in the IL11 gene is associated with ulcerative colitis. Genes Immun [Internet]. Nature Publishing Group; 2002 [cited 2018 Apr 19];3:494–6. Available from: http://www.nature.com/articles/6363897 UR - http://www.nature.com/articles/6363897 ID - ref23 ER - TY - STD TI - Herrlinger KR, Witthoeft T, Raedler A, Bokemeyer B, Krummenerl T, Schulzke JD, et al. Randomized, Double Blind Controlled Trial of Subcutaneous Recombinant Human Interleukin-11 Versus Prednisolone in Active Crohn’s Disease. Am J Gastroenterol [Internet]. Nature Publishing Group; 2006 [cited 2018 Feb 28];101:793–7. Available from: http://www.nature.com/doifinder/10.1111/j.1572-0241.2005.00356.x UR - http://www.nature.com/doifinder/10.1111/j.1572-0241.2005.00356.x ID - ref24 ER - TY - STD TI - Bozza M, Bliss JL, Dorner AJ, Trepicchio WL. Interleukin-11 Modulates Th1/Th2 Cytokine Production from Activated CD4 + T Cell J Interf Cytokine Res [Internet]. Mary Ann Liebert, Inc.; 2001 [cited 2018 Jan 24];21:21–30. Available from: http://www.liebertonline.com/doi/abs/10.1089/107999001459123 UR - http://www.liebertonline.com/doi/abs/10.1089/107999001459123 ID - ref25 ER - TY - STD TI - Chen Q, Rabach L, Noble P, Zheng T, Lee CG, Homer RJ, et al. IL-11 Receptor α in the Pathogenesis of IL-13-Induced Inflammation and Remodeling. J Immunol [Internet]. American Association of Immunologists; 2005 [cited 2018 Jan 24];174:2305–13. Available from: http://www.jimmunol.org/content/174/4/2305.short UR - http://www.jimmunol.org/content/174/4/2305.short ID - ref26 ER - TY - STD TI - Orazi A, Du X, Yang Z, Kashai M, Williams DA. Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation. Lab Investig [Internet]. 1996 [cited 2018 Jan 24];75:33–42. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8683938 UR - http://www.ncbi.nlm.nih.gov/pubmed/8683938 ID - ref27 ER - TY - STD TI - Negahdaripour M, Nezafat N, Ghasemi Y. A panoramic review and in silico analysis of IL-11 structure and function. Cytokine Growth Factor Rev [Internet]. Pergamon; 2016 [cited 2018 Jan 24];32:41–61. Available from: https://www.sciencedirect.com/science/article/pii/S1359610116300387 UR - https://www.sciencedirect.com/science/article/pii/S1359610116300387 ID - ref28 ER - TY - JOUR AU - Shin, S. Y. AU - Choi, C. AU - Lee, H. G. AU - Lim, Y. AU - Lee, Y. H. PY - 2012 DA - 2012// TI - Transcriptional regulation of the interleukin-11 gene by oncogenic Ras JO - Carcinogenesis VL - 33 UR - https://doi.org/10.1093/carcin/bgs297 DO - 10.1093/carcin/bgs297 ID - Shin2012 ER - TY - JOUR AU - Chaum, E. AU - Yin, J. AU - Yang, H. AU - Thomas, F. AU - Lang, J. C. PY - 2009 DA - 2009// TI - Quantitative AP-1 gene regulation by oxidative stress in the human retinal pigment epithelium JO - J Cell Biochem VL - 108 UR - https://doi.org/10.1002/jcb.22358 DO - 10.1002/jcb.22358 ID - Chaum2009 ER - TY - JOUR AU - Reuter, B. K. AU - Pizarro, T. T. PY - 2004 DA - 2004// TI - Commentary: the role of the IL-18 system and other members of the IL-1R/TLR superfamily in innate mucosal immunity and the pathogenesis of inflammatory bowel disease: friend or foe? JO - Eur J Immunol VL - 34 UR - https://doi.org/10.1002/eji.200425351 DO - 10.1002/eji.200425351 ID - Reuter2004 ER - TY - JOUR AU - Lokau, J. AU - Agthe, M. AU - Flynn, C. M. AU - Garbers, C. PY - 2017 DA - 2017// TI - Proteolytic control of Interleukin-11 and Interleukin-6 biology JO - Biochim Biophys Acta (BBA)-Molecular Cell Res VL - 864 UR - https://doi.org/10.1016/j.bbamcr.2017.06.008 DO - 10.1016/j.bbamcr.2017.06.008 ID - Lokau2017 ER - TY - JOUR AU - Zhang, X. AU - Wu, H. AU - Dobson, J. R. AU - Browne, G. AU - Hong, D. AU - Akech, J. PY - 2015 DA - 2015// TI - Expression of the IL-11 gene in metastatic cells is supported by Runx2-Smad and Runx2-cJun complexes induced by TGFβ1 JO - J Cell Biochem VL - 116 UR - https://doi.org/10.1002/jcb.25167 DO - 10.1002/jcb.25167 ID - Zhang2015 ER - TY - JOUR AU - Kawamata, S. AU - Matsuzaki, K. AU - Murata, M. AU - Seki, T. AU - Matsuoka, K. AU - Iwao, Y. PY - 2011 DA - 2011// TI - Oncogenic Smad3 signaling induced by chronic inflammation is an early event in ulcerative colitis-associated carcinogenesis JO - Inflamm Bowel Dis VL - 17 UR - https://doi.org/10.1002/ibd.21395 DO - 10.1002/ibd.21395 ID - Kawamata2011 ER - TY - JOUR AU - Matsumoto, T. AU - Kuriwaka-Kido, R. AU - Kondo, T. AU - Endo, I. AU - Kido, S. PY - 2012 DA - 2012// TI - Regulation of osteoblast differentiation by interleukin-11 via AP-1 and Smad signaling JO - Endocr J VL - 59 UR - https://doi.org/10.1507/endocrj.EJ11-0219 DO - 10.1507/endocrj.EJ11-0219 ID - Matsumoto2012 ER - TY - STD TI - Barnes PJ. Series signalling and transcriptional regulation in inflammatory and immune cells: importance in lung biology and disease” Corticosteroid effects on cell signalling. [cited 2018 Apr 21]; Available from: https://pdfs.semanticscholar.org/0e3b/e80e3d3d0e598bb0145d40c37983242f7254.pdf UR - https://pdfs.semanticscholar.org/0e3b/e80e3d3d0e598bb0145d40c37983242f7254.pdf ID - ref36 ER - TY - STD TI - Babyatsky M, Rossiter G, Podolsky D. Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease. Gastroenterology [Internet]. W.B. Saunders; 1996 [cited 2018 Apr 21];110:975–84. Available from: https://www.sciencedirect.com/science/article/pii/S0016508596001849?via%3Dihub UR - https://www.sciencedirect.com/science/article/pii/S0016508596001849?via%3Dihub ID - ref37 ER -