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Table 1 NaB and 5-AZA-induced resistance to anti-cancer drug-5-FU in HCT116 and WiDr cells

From: Pharmacologically upregulated carcinoembryonic antigen-expression enhances the cytolytic activity of genetically-modified chimeric antigen receptor NK-92MI against colorectal cancer cells

Cell line

Treatment

IC50 of 5-FU (uM)

Mean ± SD*

P-value**

HCT116

5-FU

4.39 ± 3.10

 

0.1 mM NaB+5-FU

9.40 ± 6.03

<0.05(0.036)

1 μM 5-AZA+5-FU

11.76 ± 9.05

<0.05(0.020)

WiDr

5-FU

4.67 ± 0.55

 

0.1 mM NaB+5-FU

9.20 ± 2.74

<0.001

1 μM 5-AZA+5-FU

10.81 ± 3.34

<0.001

  1. *Results are presented as mean± SD of three independent experiments, each done in triplicate.
  2. **The groups treated with 5-FU and NaB or 5-FU and 5-AZA were significantly increase IC50 comparing to 5-FU alone treatment group in HCT116 and WiDr cells