TY - JOUR AU - Marischen, Lothar AU - Englert, Anne AU - Schmitt, Anna-Lena AU - Einsele, Hermann AU - Loeffler, Juergen PY - 2018 DA - 2018/12/18 TI - Human NK cells adapt their immune response towards increasing multiplicities of infection of Aspergillus fumigatus JO - BMC Immunology SP - 39 VL - 19 IS - 1 AB - The saprophytic fungus Aspergillus fumigatus reproduces by generation of conidia, which are spread by airflow throughout nature. Since humans are inhaling certain amounts of spores every day, the (innate) immune system is constantly challenged. Even though macrophages and neutrophils carry the main burden, also NK cells are regarded to contribute to the antifungal immune response. While NK cells reveal a low frequency, expression and release of immunomodulatory molecules seem to be a natural way of their involvement. SN - 1471-2172 UR - https://doi.org/10.1186/s12865-018-0276-6 DO - 10.1186/s12865-018-0276-6 ID - Marischen2018 ER -