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Table 2 Bivariate and multivariate analysis of risk factors for immunological failure on ART/AIDs patients attending University of Gondar Referral Hospital 2017

From: Prevalence and associated factors of treatment failure among HIV/AIDS patients on HAART attending University of Gondar Referral Hospital Northwest Ethiopia

Variables Immunological failure COR(95%CI) AOR(95%CI) P value
Yes No
Age 18–29 13 (24.1%) 41 (75.9%) 2.58 (0.95–7.04) 0.96 (0.25–3.66) 0.955
30–39 18 (10.7%) 151 (89.3%) 0.97 (0.39–2.45) 0.74 (.26–2.09) 0.570
40–49 18 (13.2%) 118 (89.3%) 1.23 (0.49–3.14) 1.19 (0.43–3.34) 0.731
> = 50 7 (10.9%) 57 (89.1%)    Ref
Educational status Illiterate 18 (14.9%) 103 (85.1%) 2.33 (0.65–8.34) 2.05 (0.53–7.92) 0.297
primary school 17 (14.5%) 100 (85.5%) 2.27 (0.63–8.16) 2.14 (0.57–0.14) 0.265
secondary school 18 (12.7%) 124 (87.3%) 1.94 (0.54–6.91) 1.55 (0.41–5.94) 0.522
Tertiary 3 (7.0%) 40 (93.0%)    Ref
Duration on ART in year <=6 30 (18.5%) 132 (81.5%) 2.05 (1.16–3.62) 2.07 (1.11–3.87) 0.023*
> 6 26(10%) 235 (90)%    Ref
Initial regimen D4T + 3TC+ EFV 1 (3.4%) 28 (96.6%) 0.22 (0.03–1.77) 0.29 (0.04–2.49) 0.262
AZT +3TC + NVP 20 (12.8%) 136 (87.2%) 0.89 (0.41–1.98) 0.73 (0.28–1.92) 0.529
AZT + 3TC + EFV 2 (6.7%) 28 (93.3%) 0.44 (0.09–2.09) 0.46 (0.09–2.49) 0.370
TDF + 3TC + EFV 10 (11.5%) 77 (88.5%) 0.79 (0.32–1.98) 0.50 (0.16–1.59) 0.239
TDF + 3TC + NVP 6(19.4%) 25 (80.6%) 1.46(0.49–4.37) 0.99 (0.29–3.45) 0.996
D4T + 3TC + NVP 2 (33.3%) 4 (66.7%) 3.04 (0.49–18.67) 1.173 (0.18–7.49) 0.866
AZT+ 3TC + NVP(4c) 4 (66.7%) 2 (33.3%) 12.18 (1.99–74.67) 12.90 (1.17–142.67) 0.051
D4T + 3TC + NVP(4a) 11 (14.1%) 67 (85.9%)    Ref
Viral load > = 20 33(28%) 82(72%) 4.987(2.775–8.963) 5.19 (2.81–9.62) 0.0001*
<  20 23(7%) 285(93%)    Ref
  1. Note:* Has significant association
  2. Those variables with in p value < 0.2 under bivariate analysis were included with in multivariate analysis
  3. COR crude odds ratio, AOR adjusted odds ratio, Ref reference, CI confidence interval, p significant value, D4T Stavudine, TDF TenofovirDisoproxilFumarate, AZT/ 3TC Zidovudine/Lamivudine, EFV Efavirenze, NVP Nevirapine