Fig. 8

Effects of cmah^−/− background on HIV-1 and IgG clearance from blood circulation and tissue luciferase expression delivered by rAAV2/DJ8. a Clearance of HIV-1 from mouse peripheral blood. b Clearance of human IgG from the peripheral blood (n = 5). Percentage of human IgG determined at 30 min after injection of 100 μl of a 10% human IgG (10 mg/mouse) were 10.6 ± 1.2 and 11.0 ± 0.9 μg/ml for NSG-cmah^−/− and wild type mice, respectively. Five to three blood samples were collected for days 1–14 time points, mean and SEM are shown. End-point IgG concentrations in peripheral blood were 1.1 ± 0.04 and 0.9 ± 0.03 μg/ml for NSG-cmah^−/− and wild type mice, respectively. c Luciferase RNA expression at 32 days post intravenous injection in liver, spleen, and brain of NSG-cmah^−/− (n = 5) and wild type mice (n = 5). (#) P ≤ 0.05 were considered significant by two-tail Mann-Whitney test