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Table 1 Targets of IgG antibodies with 10-fold or greater in AS patients

From: Anti-SIRT1 autoantibody is elevated in ankylosing spondylitis: a potential disease biomarker

Name Fold change Functions
SIRT1 29.3 NAD-dependent protein deacetylase sirtuin-1
ATG16L1 26.4 Autophagy
VCY 23.0 Spermatogenesis
UBE2R2 20.5 Ubiquitin-conjugating enzyme
PLEKHA8 19.9 Cargo transport protein
ZNF207 16.8 Kinetochore- and microtubule-binding protein
MAPK11 16.3 MAP kinase signal transduction pathway
TNK1 14.9 Negatively regulating RAS-MAPK pathway
ND7 14.7 NADH dehydrogenase subunit 7
SPN 14.3 Regulating multiple T-cell functions
GORASP2 13.1 Golgi reassembly-stacking protein 2
IFI6 11.6 Regulating apoptosis, anti-viral activity
GAB1 11.1 GRB2-associated-binding protein 1
RBPJ 11.0 Playing a central role in Notch signaling
THUMPD1 10.6 tRNA acetylation
CCDC83 10.2 Coiled-coil domain-containing protein
CCDC184 10.1 Coiled-coil domain-containing protein
CNST 10.0 Required for targeting of connexins to the plasma membrane