Skip to main content

Table 1 Targets of IgG antibodies with 10-fold or greater in AS patients

From: Anti-SIRT1 autoantibody is elevated in ankylosing spondylitis: a potential disease biomarker

Name

Fold change

Functions

SIRT1

29.3

NAD-dependent protein deacetylase sirtuin-1

ATG16L1

26.4

Autophagy

VCY

23.0

Spermatogenesis

UBE2R2

20.5

Ubiquitin-conjugating enzyme

PLEKHA8

19.9

Cargo transport protein

ZNF207

16.8

Kinetochore- and microtubule-binding protein

MAPK11

16.3

MAP kinase signal transduction pathway

TNK1

14.9

Negatively regulating RAS-MAPK pathway

ND7

14.7

NADH dehydrogenase subunit 7

SPN

14.3

Regulating multiple T-cell functions

GORASP2

13.1

Golgi reassembly-stacking protein 2

IFI6

11.6

Regulating apoptosis, anti-viral activity

GAB1

11.1

GRB2-associated-binding protein 1

RBPJ

11.0

Playing a central role in Notch signaling

THUMPD1

10.6

tRNA acetylation

CCDC83

10.2

Coiled-coil domain-containing protein

CCDC184

10.1

Coiled-coil domain-containing protein

CNST

10.0

Required for targeting of connexins to the plasma membrane