Fig. 1

Genetic abrogation of CEACAM1 leads to decreased body surface temperature and increased diarrhea and IL-6 production in response to LPS (a) Body surface temperature of WT and Ceacam1^−/− mice in response to LPS (i.p. injection, 10 mg/kg) (n = 10 each group). * p < 0.05 in comparison with WT treated with LPS. # p < 0.05 in comparison with WT treated with normal saline. (b) Diarrheogenic activity of Ceacam1^−/− mice in response to LPS (i.p. injection, 10 mg/kg) (n = 17, each group). (c-f) Quantification of 4 serum cytokines of Wild type (WT) and Ceacam1^−/− mice (KO) in response to LPS (i.p. injection, 10 mg/kg) (n = 10, each group). * p < 0.05 in comparison with WT