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Fig. 3 | BMC Immunology

Fig. 3

From: Similar immune mechanisms control experimental airway eosinophilia elicited by different allergens and treatment protocols

Fig. 3

TSLPR deficiency results in reduced airway inflammation in OVA and HDM models. (ad) C57BL/6 and TSLPR-KO mice were immunized and challenged with OVA or HDM as in Fig. 1; PBS refers to C57BL/6 mice that were mock-immunized and challenged with OVA or HDM. Total cell counts, percent and number of eosinophils were evaluated by flow cytometry; bar graphs show mean + SEM/mouse from two combined experiments each using 5–8 mice per group. Histopathological scores were calculated on 6–10 mice per condition, which were selected from both experiments. Peribronchiolar and perivascular inflammation scores are displayed as median +/− interquartile range; the percent PAS-positive staining in bronchiolar epithelial cells is shown as mean + SEM. (e) In vitro activated OTII Th2 cells were transferred into WT or TSLPR-KO mice 1 day before i.n. OVA challenge; data refer to 6–7 mice per group. In A-D, P values refer to the comparison between the sensitised and challenged C57BL/6 and TSLPR-KO groups. ***, p < 0.001; **, p < 0.01; *, p < 0.05; ns, not significant

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