Fig. 6

Female mice develop exacerbated airway eosinophilia in systemic HDM models compared to males. (a–d) Male and female C57BL/6 mice were immunized and challenged with OVA or HDM as in Fig. 1; PBS mice were mock-immunized and challenged with OVA or HDM. Total cell counts, percent and number of eosinophils were evaluated by flow cytometry; bar graphs show mean +/− SEM/mouse from several combined independent experiments each using 5–8 mice per group. P values refer to the comparison between males and females within sensitised and challenged groups, or mock-sensitised and challenged groups. ***, p < 0.001; **, p < 0.01; *, p < 0.05; ns, not significant