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Table 1 Characteristics of 219 adults with IgG subclass deficiency1

From: Clinical and laboratory associations of mannose-binding lectin in 219 adults with IgG subclass deficiency

Characteristic Mannose-binding lectin ≤50 ng/mL (n = 36) Mannose-binding lectin > 50 ng/mL (n = 183) Value of p2
Mean age, years (SD) 54 ± 15 51 ± 14 0.2909
Male, % (n) 19.4 (7) 16.9 (31) 0.8096
Mean body mass index, kg/m2 (SD) 31.3 ± 7.0 29.6 ± 6.9 0.1865
Upper respiratory tract infection, % (n)4 83.3 (30) 92.3 (169) 0.1094
Lower respiratory tract infection, % (n)4 75.0 (27) 82.5 (151) 0.3487
Diabetes mellitus, % (n) 4 13.9 (5) 15.8 (29) 1.0000
Autoimmune condition(s), % (n)4,5 50.0 (18) 52.5 (96) 0.8560
Atopy, % (n)4 33.3 (12) 30.6 (56) 0.8440
Other allergy, % (n) 4 44.4 (16) 40.4 (74) 0.7124
Corticosteroid therapy, % (n) 30.5 (11) 36.6 (67) 0.5702
Mean total IgG, mg/dL (SD)6 805 ± 218 775 ± 207 0.4555
Subnormal IgG1, % (n) 69.4 (25) 66.7 (122) 0.8472
Subnormal IgG2, % (n) 13.9 (5) 8.7 (16) 0.3538
Subnormal IgG3, % (n) 61.1 (22) 66.7 (122) 0.5662
Subnormal IgG4, % (n) 2.8 (1) 7.7 (14) 0.4750
Subnormal IgA, % (n) 2.8 (1) 4.9 (9) 1.0000
Subnormal IgM, % (n) 22.2 (8) 10.4 (19) 0.0565
  1. 1Abbreviations: SD standard deviation. Subnormal Ig levels were defined as those > 2 SD below the respective means: IgG1 < 4.2 g/L (< 422 mg/dL); IgG2 < 1.2 g/L (< 117 mg/dL); IgG3 < 0.4 g/L (< 41 mg/dL); IgG4 0 g/L (< 1 mg/dL); IgA < 700 mg/L (< 70 mg/dL); and IgM < 400 mg/L (< 40 mg/dL) [15]
  2. 2Comparisons were made with Fisher’s exact test (two-tailed). These are nominal values of p. Bonferroni correction for 17 comparisons yielded a revised p for significance of < 0.0020
  3. 3Upper respiratory tract infection was defined as reports of sinusitis, otitis media, mastoiditis, pharyngitis, and tonsillitis. Lower respiratory tract infection was defined as reports of bronchitis, pneumonia, and bronchiectasis
  4. 4These conditions were diagnosed before referral for the present evaluations
  5. 5These autoimmune conditions (n) were diagnosed in 114 of 219 patients (52.1%): Hashimoto thyroiditis (44); rheumatoid arthritis (27); Sjögren syndrome (26); systemic lupus erythematosus (20); psoriatic arthritis (8); ankylosing spondylitis (6); Graves disease, psoriasis, and Raynaud phenomenon (5 each); inflammatory arthritis (3); autoimmune diabetes, Crohn disease, multiple sclerosis, polyarthritis with iritis/uveitis, and sarcoidosis, (2 each); and chronic inflammatory demyelinating polyneuropathy, Guillain-Barré syndrome, mixed connective tissue disorder, myasthenia gravis, polymyositis, transverse myelitis, Schnitzler syndrome, Sweet syndrome, ulcerative colitis, undifferentiated connective tissue disease, and vitiligo (1 each). Two or more autoimmune conditions were diagnosed in 46 of 219 patients (21.0%)
  6. 6Proportions of patients with and without MBL ≤50 ng/mL who had total IgG < 7.0 g/L (< 700 mg/dL) did not differ significantly (38.9% (n = 14) vs. 39.0% (n = 71); p = ~ 1.0000)