Comprehensive analyses of long non-coding RNA expression profiles by RNA sequencing and exploration of their potency as biomarkers in psoriatic arthritis patients

Table 4 Correlation of validated lncRNAs with PSA patients’ characteristics (continuous variables)

	lnc-RP11-701H24.7	lnc-RNU12	lnc-SNORD3A	lnc-TRAV1–2	lnc-TRAV1–1
Age
correlation coefficient r	0.103	0.014	−0.036	0.033	0.050
P value	0.326	0.893	0.735	0.750	0.635
Disease duration of psoriasis
correlation coefficient r	−0.029	− 0.019	− 0.024	− 0.021	0.137
P value	0.789	0.857	0.822	0.844	0.198
Disease duration of arthritis
correlation coefficient r	0.063	0.046	0.009	−0.056	0.151
P value	0.562	0.675	0.931	0.604	0.161
Affected BSA
correlation coefficient r	−0.077	−0.103	−0.097	− 0.054	0.091
P value	0.465	0.326	0.354	0.605	0.387
PASI score
correlation coefficient r	0.005	0.214	−0.071	−0.281	0.091
P value	0.963	0.039	0.496	0.006	0.383
CRP
correlation coefficient r	0.172	0.269	0.055	−0.189	−0.035
P value	0.155	0.024	0.648	0.118	0.772
ESR
correlation coefficient r	0.242	0.115	−0.012	−0.098	−0.021
P value	0.049	0.353	0.925	0.432	0.867
SJC
correlation coefficient r	0.284	0.198	0.048	0.065	−0.061
P value	0.007	0.061	0.656	0.540	0.569
TJC
correlation coefficient r	0.273	0.199	−0.085	−0.025	0.066
P value	0.009	0.060	0.426	0.819	0.535
Pain VAS score
correlation coefficient r	0.239	0.133	−0.011	0.002	0.025
P value	0.021	0.202	0.916	0.984	0.811
PGA score
correlation coefficient r	0.075	0.263	−0.033	−0.227	0.063
P value	0.475	0.011	0.756	0.029	0.547

Data were presented as correlation coefficient r and P value. Correlation was determined by Spearman test. P < 0.05 was considered as significant. LncRNA Long non-coding RNA, PSA Psoriatic arthritis, BSA Body surface area, PASI Psoriasis area and severity index, CRP C-reactive protein, ESR Erythrocyte sedimentation rate, SJC Swollen joint count, TJC Tender joint count, VAS Visual analogue scale, PGA Patients’ global assessment

ISSN: 1471-2172