Soluble CD14 subtype (sCD14-ST) as biomarker in neonatal early-onset sepsis and late-onset sepsis: a systematic review and meta-analysis

Table 1 Overview and characteristics of included studies

Sepsis type	Author	Case definition	Cases	GA	BW	Controls	GA	BW	PATHFAST^b	Sampling time^c
Sepsis type	Author	Case definition	N	Weeks	Gram	N	Weeks	Gram	PATHFAST^b	Days
EOS	Montaldo [9]	Culture positive	32	29.9 ± 1.1	1082 ± 205	38	30.2 ± 1.4	1102 ± 192	M	T = 0, ½, 1 and 2
	Ozdemir [11]	Clinical + laboratory signs	29	39.1 ± 0.9	3286 ± 461	40	39.0 ± 1.0	3379 ± 421	M	T = 0, 3 and 7
	Motalib [28]	Clinical signs	28	37.6 ± 1.7	3242 ± 269	34	38.3 ± 1.3	3198 ± 235	M	T = 0 and 7
LOS	Poggi [10]	Clinical + laboratory signs	19	25.6 ± 2.0	684 ± 215	21	28.8 ± 2.0	1021 ± 233	G	T = 0, 1, 3 and 5
LOS	Topcuoglu [12]	Clinical signs	42	28.4 ± 2.6	1084 ± 318	40	28.9 ± 2.8	1140 ± 338	M	T = 0, 2 and 6
Controls	Mussap [29]	n/a	n/a	n/a	n/a	26	26–36	n/a	G	T = 1–7^d
Controls	Pugni [31]	n/a	n/a	n/a	n/a	684	≥ 24	n/a	M	T = 3–7^d
Combined^a	Miyosawa [32]	Culture positive + clinical signs	13	30.3 ± 6.6	1644 ± 1202	18	31.2 ± 3.4	1520 ± 605	M	T = 0, 1 and 2
	Mussap [30]	Culture positive/ clinical signs	25	35.0 (31.0–41.0)	2508 (1295–3160)	25	34.0 (29.0–36.0)	1750 (1027–3000)	G	T = 0
	Osman [27]	Clinical + laboratory signs	40	37.5 ± 1.2	2518 ± 532	15	37.8 ± 1.6	2581 ± 513	M	T = 0
	Iskandar [33]	Culture positive	35	n/a	n/a	16	n/a	n/a	M	T = 0
	Xiao [13]^e	Culture positive	42	37.9 ± 2.4	2950 ± 639	53	38.8 ± 1.4	3094 ± 586	M	T = 0, 3 and 5
		Clinical signs	54	37.9 ± 2.6	3054 ± 563
Total			359			1010

EOS early-onset sepsis, LOS late-onset sepsis, ^astudies that analyzed both EOS and LOS;
GA gestational age in mean ± SD or median (IQR), BW birth weight (mean ± SD); n/a not applicable
^bM Mitsubishi Chemical Medience Corporation, Tokyo, Japan; G Gepa Diagnostics, Milan, Italy
^cDays after admission/medical evaluation; ^ddays after birth; ^eOnly blood culture confirmed cases and healthy controls used

ISSN: 1471-2172