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Table 1 Overview and characteristics of included studies

From: Soluble CD14 subtype (sCD14-ST) as biomarker in neonatal early-onset sepsis and late-onset sepsis: a systematic review and meta-analysis

Sepsis type Author Case definition Cases GA BW Controls GA BW PATHFASTb Sampling timec
N Weeks Gram N Weeks Gram Days
EOS Montaldo [9] Culture positive 32 29.9 ± 1.1 1082 ± 205 38 30.2 ± 1.4 1102 ± 192 M T = 0, ½, 1 and 2
Ozdemir [11] Clinical + laboratory signs 29 39.1 ± 0.9 3286 ± 461 40 39.0 ± 1.0 3379 ± 421 M T = 0, 3 and 7
Motalib [28] Clinical signs 28 37.6 ± 1.7 3242 ± 269 34 38.3 ± 1.3 3198 ± 235 M T = 0 and 7
LOS Poggi [10] Clinical + laboratory signs 19 25.6 ± 2.0 684 ± 215 21 28.8 ± 2.0 1021 ± 233 G T = 0, 1, 3 and 5
Topcuoglu [12] Clinical signs 42 28.4 ± 2.6 1084 ± 318 40 28.9 ± 2.8 1140 ± 338 M T = 0, 2 and 6
Controls Mussap [29] n/a n/a n/a n/a 26 26–36 n/a G T = 1–7d
Pugni [31] n/a n/a n/a n/a 684 ≥ 24 n/a M T = 3–7d
Combineda Miyosawa [32] Culture positive + clinical signs 13 30.3 ± 6.6 1644 ± 1202 18 31.2 ± 3.4 1520 ± 605 M T = 0, 1 and 2
Mussap [30] Culture positive/ clinical signs 25 35.0 (31.0–41.0) 2508 (1295–3160) 25 34.0 (29.0–36.0) 1750 (1027–3000) G T = 0
Osman [27] Clinical + laboratory signs 40 37.5 ± 1.2 2518 ± 532 15 37.8 ± 1.6 2581 ± 513 M T = 0
Iskandar [33] Culture positive 35 n/a n/a 16 n/a n/a M T = 0
Xiao [13]e Culture positive 42 37.9 ± 2.4 2950 ± 639 53 38.8 ± 1.4 3094 ± 586 M T = 0, 3 and 5
  Clinical signs 54 37.9 ± 2.6 3054 ± 563      
Total    359    1010     
  1. EOS early-onset sepsis, LOS late-onset sepsis, astudies that analyzed both EOS and LOS;
  2. GA gestational age in mean ± SD or median (IQR), BW birth weight (mean ± SD); n/a not applicable
  3. bM Mitsubishi Chemical Medience Corporation, Tokyo, Japan; G Gepa Diagnostics, Milan, Italy
  4. cDays after admission/medical evaluation; ddays after birth; eOnly blood culture confirmed cases and healthy controls used