TY - JOUR AU - Chu, Nathaniel D. AU - Bi, Haixin Sarah AU - Emerson, Ryan O. AU - Sherwood, Anna M. AU - Birnbaum, Michael E. AU - Robins, Harlan S. AU - Alm, Eric J. PY - 2019 DA - 2019/06/21 TI - Longitudinal immunosequencing in healthy people reveals persistent T cell receptors rich in highly public receptors JO - BMC Immunology SP - 19 VL - 20 IS - 1 AB - The adaptive immune system maintains a diversity of T cells capable of recognizing a broad array of antigens. Each T cell’s specificity for antigens is determined by its T cell receptors (TCRs), which together across all T cells form a repertoire of millions of unique receptors in each individual. Although many studies have examined how TCR repertoires change in response to disease or drugs, few have explored the temporal dynamics of the TCR repertoire in healthy individuals. SN - 1471-2172 UR - https://doi.org/10.1186/s12865-019-0300-5 DO - 10.1186/s12865-019-0300-5 ID - Chu2019 ER -