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Table 1 Liver proteins with strong DS-affinity

From: A comprehensive autoantigen-ome of autoimmune liver diseases identified from dermatan sulfate affinity enrichment of liver tissue proteins

a

  

ANA (antinuclear autoantigens)

Ref.

10

IPI00329998.3

H4

Histone H4

[8]

6

IPI00114642.4

Hist1h2bj

Histone H2B type 1-F/J/L

[9]

5

IPI00153400.2

H2afj

Histone H2A.J

[9]

5

IPI00111957.3

Hist1h2ba

Histone H2B type 1-A

[9]

4

IPI00137852.5

H2afy

Core histone macro-H2A.1

[10]

2

IPI00404590.1

H1f0

Histone H1.0

[11]

3

IPI00119220.1

Snrpd2

Small nuclear ribonucleoprotein Sm D2

[12]

2

IPI00114052.1

Snrpb

Small nuclear ribonucleoprotein-associated protein B

[13]

2

IPI00122350.4

Snrpa

U1 small nuclear ribonucleoprotein A

[14]

2

IPI00133955.1

Snrpe

Small nuclear ribonucleoprotein E

[15]

3

IPI00131988.1

Mrpl49

39S ribosomal protein L49, mitochondria

[16]

3

IPI00311236.1

Rpl7

60S ribosomal protein L7

[17]

2

IPI00122421.5

Rpl27

60S ribosomal protein L27

[18]

2

IPI00222549.6

Rpl30

60S ribosomal protein L30

[16]

3

IPI00124287.1

Pabpc1

Polyadenylate-binding protein

[19]

2

IPI00119959.1

Banf1

Barrier-to-autointegration factor

[20]

   

SMA (anti-smooth muscle autoantigens) / Cytoskeleton

 

6

IPI00753793.2

Spna2

Isoform 2 of Spectrin alpha chain

[21]

5

IPI00123181.4

Myh9

Myosin-9

[22]

2

IPI00109044.8

G15Rik

Myosin light chain, regulatory B-like

[23]

2

IPI00354819.5

Myl6

Isoform Smooth muscle of Myosin light chain 6

[24]

2

IPI00230435.1

Lmna

Isoform C2 of Lamin-A

[25]

   

AMA (anti-mitochondrial autoantigens)

 

13

IPI00319992.1

Hspa5

78 kDa glucose-regulated protein (Grp78)

[26]

13

IPI00114209.1

Glud1

Glutamate dehydrogenase 1, mitochondria

[27, 28]

11

IPI00131424.3

Cpt2

Carnitine O-palmitoyltransferase 2, mitochondria

 

6

IPI00133903.1

Hspa9

Stress-70 protein, mitochondria (Grp75)

[29]

3

IPI00111908.8

Cps1

Carbamoyl-phosphate synthase [ammonia], mitochondria

 

3

IPI00273146.1

Chdh

Choline dehydrogenase, mitochondria

 

2

IPI00129577.1

Aifm1

Apoptosis-inducing factor 1 (Aif, Pdcd8, programmed cell death protein 8), mitochondria

[30]

   

LKM (liver-kidney microsomal autoantigens)

 

3

IPI00111936.1

Ugt1a9

UDP-glucuronosyltransferase 1-9 (bilirubin-specific)

[31]

3

IPI00112322.2

Ugt2b5

UDP glucuronosyltransferase 2 family, polypeptide B5

[32]

2

IPI00230113.5

Cyb5

Microsomal cytochrome b5

[33]

2

IPI00131771.3

Cox6c

Cytochrome c oxidase subunit 6c

 

2

IPI00169666.3

Ugt2b34

UDP glucuronosyltransferase 2 family, polypeptide B3

[32]

2

IPI00230108.6

Pdia3

Protein disulfide-isomerase A

[34]

2

IPI00134746.5

Ass1

Argininosuccinate synthase

 

2

IPI00387289.3

Ces3

Carboxylesterase

[35]

   

Peroxisomal proteins

 

3

IPI00112549.1

Acsl1

Long-chain-fatty-acid-CoA ligase

 

2

IPI00312058.5

Cat

Catalase

[36, 37]

2

IPI00223367.5

Uox

Uricase

 

2

IPI00125325.1

Decr2

Peroxisomal 2,4-dienoyl-CoA reductase

 

2

IPI00125813.1

Dpp4

Dipeptidyl peptidase (CD26)

[38, 39]

  1. aColumns left to right: Number of peptides identified for the protein by mass spectrometry; Protein ID; Gene name; Protein name; Reference (if any) reporting autoantibodies induced by the protein