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Table 2 Liver proteins with moderate DS-affinity

From: A comprehensive autoantigen-ome of autoimmune liver diseases identified from dermatan sulfate affinity enrichment of liver tissue proteins

a

  

ANA (antinuclear autoantigens)

Ref.

8

IPI00230730.4

Hist2h3b

Histone H3.2

[41]

4

IPI00223713.5

Hist1h1c

Histone H1.2

[42]

2

IPI00459318.1

Hist1h2bp

Putative uncharacterized protein, histone

[9]

2

IPI00136632.3

H2afy3

Histone H2A member Y3

[43]

2

IPI00320149.2

H2afv

Histone H2A member V

[9]

6

IPI00308706.4

Rpl5

60S ribosomal protein L5

 

5

IPI00127085.6

Rpl10a

60S ribosomal protein L10a

 

3

IPI00555113.2

Rpl18

60S ribosomal protein L18

 

3

IPI00138892.2

Uba52

Ubiquitin-60S ribosomal protein L40

 

2

IPI00122598.3

EG382723

Similar to ribosomal protein L10

 

5

IPI00339468.4

Dhx9

Isoform 2 of ATP-dependent RNA helicase, DNA helicase II

[44]

4

IPI00121596.3

Prpf8

Pre-mRNA-processing-splicing factor 8

 

3

IPI00109764.2

Top1

DNA topoisomerase 1 (Scl-70)

[45]

2

IPI00322749.3

Snrpd1

Small nuclear ribonucleoprotein Sm D1

[46]

2

IPI00120162.1

Csnk2a1

Casein kinase II subunit alpha

[17]

   

SMA (anti-smooth muscle autoantigens) / Cytoskeleton

 

6

IPI00400300.1

Lmna

Isoform C of Lamin-A

[47]

4

IPI00113886.1

Lmnb2

Isoform B3 of Lamin-B

[48]

2

IPI00126191.5

Lmnb2

Isoform B2 of Lamin-B

[49]

2

IPI00113824.1

Hspg2

Basement membrane-specific heparan sulfate proteoglycan core protein

[50]

   

AMA (anti-mitochondrial autoantigens)

 

5

IPI00331555.2

Bckdha

Branched chain keto acid dehydrogenase E1, alpha polypeptide (mitochondrion matrix)

[51]

5

IPI00111877.1

Ssbp1

Single-stranded DNA-binding protein, mitochondria

 

4

IPI00153144.3

Suox

Sulfite oxidase, mitochondria

[52]

3

IPI00133208.3

Hspa1l

Heat shock 70 kDa protein 1L

[53]

2

IPI00323357.3

Hspa8

Heat shock cognate 71 kDa protein

[54]

3

IPI00420718.4

Hmgcs2

Hydroxymethylglutaryl-CoA synthase, mitochondria

[27]

3

IPI00223092.5

Hadha

Trifunctional enzyme subunit alpha, mitochondria

 

3

IPI00135651.1

Slc25a13

Calcium-binding mitochondrial carrier protein Aralar2

 

3

IPI00111885.1

Uqcrc1

Cytochrome b-c1 complex subunit 1, mitochondria

[33]

3

IPI00132799.4

C1qbp

Complement component 1 q subcomponent binding protein

 

2

IPI00127841.3

Slc25a5

ADP/ATP translocase (mitochondrion inner membrane)

 

2

IPI00387379.1

Decr1

2,4-dienoyl-CoA reductase, mitochondria

 
   

LKM (liver-kidney microsomal autoantigens)

 

6

IPI00117914.3

Arg1

Arginase-1

[55]

6

IPI00115679.1

Ganab

Isoform 2 of Neutral alpha-glucosidase A

[56]

4

IPI00621548.2

Por

NADPH-cytochrome P450 reductase

[57]

4

IPI00134691.3

Ugt1a1

UDP-glucuronosyltransferase 1-1

[58]

2

IPI00110556.1

Cyp2e1

Cytochrome P450 2E1

[59, 60]

2

IPI00321644.3

Cyp2d26

Cytochrome P450 2D26 (mouse) (LKM1 human)

[31]

   

Peroxisomal proteins

 

6

IPI00127558.3

Acox1

Peroxisomal acyl-coenzyme A oxidase

 

6

IPI00127276.1

Ehhadh

Enoyl-Coenzyme A hydratase/3-hydroxyacyl CoA dehydrogenase (peroxisomal bifunctional enzyme)

[16]

2

IPI00331628.5

Hsd17b4

Peroxisomal multifunctional enzyme type (17 beta-hydroxysteroid dehydrogenase type 4)

[61]

   

Miscellaneous

 

4

IPI00115599.6

Hsd11b1

Corticosteroid 11-beta-dehydrogenase isozyme

 

3

IPI00117705.1

Ddost

Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48 kDa subunit

 

3

IPI00313236.3

Slc27a5

Bile acyl-CoA synthetase

 

2

IPI00309035.2

Rpn1

Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1 (ribophorin 1)

 

2

IPI00127016.1

Hsd17b6

Hydroxysteroid 17-beta dehydrogenase

[62]

2

IPI00130985.1

Rdh7

Retinol dehydrogenase

 
  1. aColumns left to right: Number of peptides identified for the protein by mass spectrometry; Protein ID; Gene name; Protein name; Reference (if any) reporting autoantibodies induced by the protein