Table 5 Geometric mean titres of levels of total IgG in day 140 sera to the homologous FVO AMA1 antigen and 3 heterologous (3D7, HB3, and CAMP) variants (N = 4) rabbits
From: Identification of adjuvants for clinical trials performed with Plasmodium falciparum AMA1 in rabbits
Group | FVO | 3D7 | HB3 | CAMP |
|---|---|---|---|---|
Stable o/w Emulsion (SE) | 240 (14 to 4064) | 22 (1 to 519) | 74 (4 to 1471) | 49 (2 to 1057) |
SE-Glucopyranosyl Lipid A (GLA) | 124 (5 to 3303) | 40 (2 to 828) | 56 (3 to 1111) | 63 (4 to 976) |
Liposomes | 2 (> 0 to 23) | 1 (> 0 to 8) | 3 (1 to 13) | 4 (> 0 to 42) |
Liposomes-GLA | 12 (2 to 70) | 18 (3 to 108) | 7 (2 to 23) | 5 (2 to 15) |
CoVaccine HT™ | 3397 (884 to 13049) | 858 (54 to 13566) | 1320 (218 to 7983) | 1764 (280 to 11099) |
ImSaVac-P | 272 (163 to 453) | 60 (10 to 376) | 112 (42 to 301) | 109 (29 to 408) |
ImSaVac-P o/w | 36 (6 to 222) | 22 (3 to 180) | 17 (1 to 342) | 18 (1 to 553) |