Increased circulating Tfh to Tfr ratio in chronic renal allograft dysfunction: a pilot study

BMC Immunology

Table 2 Multi-regression analysis

Model 1 Linear regression analysis for eGFR
	Standardized coefficient			P-value
Gender	−0.207			0.110
Age	−0.193			0.225
Transplantation duration	−0.191			0.195
Pre-PRA	0.015			0.909
HLA mismatch	0.025			0.852
Immunosuppressant	0.094			0.548
cTfh to cTfr ratio	−0.420			0.012
CXCR5⁺STAT3⁺ on CD4⁺	−0.236			0.374
CXCR5⁺STAT5⁺ on CD4⁺	0.273			0.269
Tregs	0.101			0.533
CXCL13	−0.162			0.303
Model 2 Logistic regression analysis for CAD
	OR	OR 95% CI		P-value
Gender	9.964	0.185	535.386	0.258
Age	0.993	0.838	1.176	0.932
Transplantation duration	1.042	1.007	1.078	0.018
Pre-PRA	0.912	0.770	1.080	0.284
HLA mismatch	0.827	0.397	1.722	0.612
Immunosuppressant	0.541	0.106	2.750	0.459
cTfh to cTfr ratio	1.043	1.004	1.085	0.031
CXCR5⁺STAT3⁺ on CD4⁺	1.093	0.733	1.628	0.663
CXCR5⁺STAT5⁺ on CD4⁺	0.760	0.492	1.174	0.216
Tregs	0.971	0.276	3.417	0.963
cTfr	3.304	0.029	375.073	0.621
CXCL13	1.023	0.968	1.082	0.415

Model 1. P-value for linear regression equation was 0.004 by multiple linear regression analysis including age, gender, transplantation duration, Pre-PRA, HLA mismatch, immunosuppressant, cTfh to cTfr ratio, CXCR5⁺STAT3⁺ on CD4⁺ cells, CXCR5⁺STAT5⁺ on CD4⁺ cells, Treg, CXCL13; Model 2. R square for logistic regression was 0.681 by multiple logistic regression analysis including age, gender, transplantation duration, Pre-PRA, HLA mismatch, immunosuppressant, cTfh to cTfr ratio, CXCR5⁺STAT3⁺ on CD4⁺ cells, CXCR5⁺STAT5⁺ on CD4⁺ cells, cTfr, Treg, CXCL13; P-value < 0.05 was shown in bold. Pre-PRA panel reactive antibodies prior to transplantation, OR odds ratio, CI confidence intervals

ISSN: 1471-2172