Fig. 4From: CD4+ T cell exhaustion revealed by high PD-1 and LAG-3 expression and the loss of helper T cell function in chronic hepatitis BEffect of LAG-3 and PD-L1 blockade on Th1 cytokine release. IFN-γ, IL-2 and TNF-α expression on CD4+ T cells after HBV antigen stimulation with anti-IgG1 (isotype), anti-LAG-3, anti-PD-1 and anti-LAG-3 together with anti-PD-1 for 48 h. *P < 0.05, **P < 0.01, ***P < 0.001Back to article page