Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations

BMC Immunology

Table 5 Characteristics of 59 index patients with subnormal IgGSc and total serum IgG > 700 mg/dL

Characteristic	Response^a (n = 31)	Non-response^a (n = 28)	Value of p^*
Male, % (n)	9.7 (3)	25.0 (7)	0.1113
Mean age, y (± 1 SD)	47 ± 11	41 ± 13	0.3856
Mean body mass index, kg/m² (± 1 SD)	27.7 ± 9.7	28.5 ± 6.4	0.7191
Autoimmune condition, % (n)	35.5 (11)	35.7 (10)	0.9853
Atopy, % (n)	12.9 (4)	46.4 (13)	0.0045
Other allergy, % (n)	4.8 (15)	53.6 (15)	0.6908
Subnormal IgG1 only, % (n)	19.4 (6)	25.0 (7)	0.6014
Subnormal IgG3 only, % (n)	51.6 (16)	60.7 (17)	0.4820
Subnormal IgG1 + IgG3 only, % (n)	29.0 (9)	14.3 (4)	0.1724
Median IgA, mg/dL	182	186	0.6132
Median IgM, mg/dL	110	89	0.7112

^aResponse was defined as protective levels of post-vaccination S. pneumoniae serotype-specific IgG (> 1.3 μg/mL) for ≥70% of serotypes tested after polyvalent pneumococcal polysaccharide vaccination
^*Comparisons were made with Student’s unpaired t-test, Mann-Whitney U test, Pearson’s χ² test or Fisher’s exact test, as appropriate. These are nominal values of p. Bonferroni correction for 11 comparisons yielded a revised p for significance of < 0.0045

ISSN: 1471-2172