Skip to main content

Table 5 Characteristics of 59 index patients with subnormal IgGSc and total serum IgG > 700 mg/dL

From: Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations

Characteristic Responsea (n = 31) Non-responsea (n = 28) Value of p*
Male, % (n) 9.7 (3) 25.0 (7) 0.1113
Mean age, y (± 1 SD) 47 ± 11 41 ± 13 0.3856
Mean body mass index, kg/m2 (± 1 SD) 27.7 ± 9.7 28.5 ± 6.4 0.7191
Autoimmune condition, % (n) 35.5 (11) 35.7 (10) 0.9853
Atopy, % (n) 12.9 (4) 46.4 (13) 0.0045
Other allergy, % (n) 4.8 (15) 53.6 (15) 0.6908
Subnormal IgG1 only, % (n) 19.4 (6) 25.0 (7) 0.6014
Subnormal IgG3 only, % (n) 51.6 (16) 60.7 (17) 0.4820
Subnormal IgG1 + IgG3 only, % (n) 29.0 (9) 14.3 (4) 0.1724
Median IgA, mg/dL 182 186 0.6132
Median IgM, mg/dL 110 89 0.7112
  1. aResponse was defined as protective levels of post-vaccination S. pneumoniae serotype-specific IgG (> 1.3 μg/mL) for ≥70% of serotypes tested after polyvalent pneumococcal polysaccharide vaccination
  2. *Comparisons were made with Student’s unpaired t-test, Mann-Whitney U test, Pearson’s χ2 test or Fisher’s exact test, as appropriate. These are nominal values of p. Bonferroni correction for 11 comparisons yielded a revised p for significance of < 0.0045