The predictive role of CD4+ cell count and CD4/CD8 ratio in immune reconstitution outcome among HIV/AIDS patients receiving antiretroviral therapy: an eight-year observation in China

Li, Chong-Xi; Li, Yu-Ye; He, Li-Ping; Kou, Jing; Bai, Jin-Song; Liu, Jun; Tian, Bo; Cao, Li-Juan; Wang, Kun-Hua; Kuang, Yi-Qun

doi:10.1186/s12865-019-0311-2

Table 2 CD4⁺ T-cell count and CD4/CD8 ratio dynamics among three groups

From: The predictive role of CD4⁺ cell count and CD4/CD8 ratio in immune reconstitution outcome among HIV/AIDS patients receiving antiretroviral therapy: an eight-year observation in China

Time post-HAART (year)	Case (n)	CD4⁺ count (cells/μl)^a	χ²	P value	CD4/CD8 ratio	χ²	P value
INRs group
0	88	52 (23,93)			0.09 (0.05,0.15)
0.5	88	115 (82,154)	65.636	< 0.001	0.16 (0.11,0.24)	46.545	< 0.001
1	88	127 (97,176)	5.628	0.018	0.19 (0.14,0.27)	13.136	< 0.001
2	88	145 (119,173)	1.943	0.0163	0.23 (0.16,0.31)	10.227	0.001
3	87	175 (139,214)	26.793	< 0.001	0.27 (0.19,0.43)	29.897	< 0.001
4	86	191 (135,234)	2.977	0.084	0.33 (0.22,0.53)	15.070	< 0.001
5	56	185 (141,226)	0.891	0.345	0.30 (0.22,0.49)	1.786	0.181
6	37	206 (151, 264)	1.324	0.250	0.33 (0.23,0.46)	0.027	0.869
7	32	199 (142, 250)	0.032	0.857	0.36 (0.24,0.50)	6.125	0.013
8	14	210 (140,346)	0.286	0.593	0.45 (0.29,0.72)	0.286	0.593
IIRs group
0	119	175 (74, 270)			0.17 (0.10,0.29)
0.5	119	255 (187, 337)	49.824	< 0.001	0.31 (0.17,0.48)	85.723	< 0.001
1	119	290 (220, 393)	28.508	< 0.001	0.37 (0.21,0.56)	17.017	< 0.001
2	119	332 (271, 410)	16.407	< 0.001	0.41 (0.27,0.65)	28.508	< 0.001
3	118	366 (292, 483)	18.880	< 0.001	0.48 (0.33,0.72)	36.915	< 0.001
4	111	412 (308, 522)	3.973	0.046	0.55 (0.36,0.71)	3.252	0.071
5	75	418 (309, 501)	1.613	0.204	0.52 (0.37,0.78)	3.853	0.050
6	51	449 (348, 542)	7.078	0.008	0.57 (0.38,0.70)	1.588	0.208
7	41	456 (332, 630)	0.220	0.639	0.64 (0.47,0.77)	5.488	0.019
8	25	464 (333, 677)	1.960	0.162	0.67 (0.55,0.86)	1.960	0.162
IRs group
0	73	314 (254, 384)			0.31 (0.25,0.38)
0.5	73	472 (386, 587)	50.973	< 0.001	0.52 (0.40,0.83)	50.973	< 0.001
1	73	529 (460, 680)	26.889	< 0.001	0.62 (0.45,0.93)	14.918	< 0.001
2	73	631 (574, 765)	30.260	< 0.001	0.74 (0.55,1.00)	38.479	< 0.001
3	73	620 (542, 763)	2.000	0.157	0.75 (0.61,1.14)	7.247	0.007
4	70	657 (528, 818)	5.714	0.017	0.83 (0.65,1.06)	1.429	0.232
5	46	656 (569, 737)	3.130	0.077	0.81 (0.63,0.94)	1.391	0.238
6	26	646 (491, 805)	0.000	1.000	0.85 (0.72,1.00)	2.462	0.117
7	18	640 (488, 841)	2.000	0.157	0.79 (0.71,1.15)	0.222	0.637
8	10	687 (569, 801)	0.400	0.527	0.80 (0.58,0.98)	0.400	0.527

^apresented as median (P_25, P₇₅)

Back to article page

ISSN: 1471-2172

Contact us

General enquiries: journalsubmissions@springernature.com

BMC Immunology

Contact us