Table 2 The allele and genotype frequencies of the genotyped SNPs in the BIRC5 gene in MS patients and healthy individuals (HWE value is a probability)
SNP | Alleles/Genotypes | MS Patients (n = 200) N (%) | Controls (n = 200) N (%) | P value | OR (95%CI) |
|---|---|---|---|---|---|
rs9904341 | C | 188 (47) | 156 (39) | 0.022 | 1.38 (1.05–1.84) |
G | 212 (53) | 244 (61) | Reference | ||
CC | 49 (24.5) | 34 (17) | 0.029 | 1.84 (1.06–3.19) | |
CG | 90 (45) | 88 (44) | 0.238 | 1.31 (0.83–2.04) | |
GG | 61 (30.5) | 78 (39) | Reference | ||
HWE | 0.287 | ||||
rs17878467 | T | 68 (17) | 73 (18.25) | 0.642 | 0.91 (0.63–1.32) |
C | 332 (83) | 327 (81.75) | Reference | ||
TT | 9 (4.5) | 4 (2) | 0.242 | 2.05 (0.62–6.80) | |
CT | 50 (25) | 65 (32.5) | 0.110 | 0.70 (0.45–1.08) | |
CC | 144 (72) | 131 (65.5) | Reference | ||
HWE | 0.21 | ||||
rs8073069 | C | 163 (40.75) | 150 (37.5) | 0.346 | 1.15 (0.86–1.52) |
G | 237 (59.25) | 250 (62.5) | Reference | ||
CC | 35 (17.5) | 26 (13) | 0.249 | 1.42 (0.78–2.59) | |
GC | 93 (46.5) | 98 (49) | 0.993 | 1.00 (0.65–1.54) | |
GG | 72 (36) | 76 (38) | Reference | ||
HWE | 0.52 | ||||