Table 3 Analytical goals for imprecision, bias, total error allowable (TEa) for p < 0.01 and p < 0.05, reference change value (RCV), Reliability coefficient (R), indices of individuality (II), and index of heterogeneity (IH) for eighteen serum biomarkers
Biomarker | Analytical goals for precision (%) | bias (%) | TE a (%) | RCV(%) | R | II | IH | ||
|---|---|---|---|---|---|---|---|---|---|
p < 0.01 | p < 0.05 | 95 | |||||||
Group I | IL-1β | 15.4 | 10.1 | 35.5 | 46.0 | 95.6 | 0.38 | 1.14 | 0.49 |
IL-6 | 10.6 | 8.5 | 26.2 | 33.6 | 66.6 | 0.55 | 0.85 | 0.35 | |
IL-1Ra | 8.5 | 11.6 | 25.6 | 31.4 | 52.7 | 0.84 | 0.42 | 0.28 | |
IFN-γ | 15.5 | 9.5 | 35.1 | 45.6 | 96.0 | 0.29 | 1.52 | 0.53 | |
TNF-α | 6.3 | 7.5 | 17.9 | 22.2 | 39.3 | 0.79 | 0.55 | 0.24 | |
Group II | IL-8 (CXCL8) | 25.7 | 14.9 | 57.3 | 74.8 | 159.2 | 0.22 | 1.70 | 0.81 |
MIP-1β (CCL4) | 10.0 | 15.1 | 31.6 | 38.4 | 61.9 | 0.87 | 0.36 | 0.32 | |
RANTES (CCL5) | 12.0 | 11.4 | 31.2 | 39.4 | 74.3 | 0.68 | 0.62 | 0.38 | |
Group III | Adiponectin | 7.95 | 12.7 | 25.8 | 31.2 | 45.2 | 0.90 | 0.34 | 0.26 |
Leptin | 15.5 | 18.7 | 44.3 | 54.8 | 96.0 | 0.79 | 0.47 | 0.50 | |
Group IV | sCD14 | 4.0 | 3.5 | 10.1 | 12.8 | 24.8 | 0.62 | 0.74 | 0.13 |
sCD40L | 4.7 | 5.2 | 12.9 | 16.1 | 38.8 | 0.52 | 0.54 | 0.21 | |
sCD163 | 4.5 | 13.6 | 21.1 | 24.1 | 27.9 | 0.97 | 0.24 | 0.21 | |
sgp130 | 3.5 | 4.1 | 9.9 | 12.3 | 21.7 | 0.79 | 0.57 | 0.13 | |
sIL-2Rα | 7.55 | 11.1 | 23.5 | 28.7 | 46.8 | 0.86 | 0.37 | 0.24 | |
sIL-6R | 8.16 | 6.5 | 20.0 | 25.5 | 50.5 | 0.55 | 0.81 | 0.26 | |
sTNF-RII | 8.7 | 8.4 | 22.8 | 28.7 | 53.9 | 0.69 | 0.70 | 0.32 | |
Group V | Neopterin | 17.5 | 12.7 | 41.6 | 53.5 | 108.4 | 0.47 | 0.96 | 0.56 |