Fig. 3

GO analysis and GSEA. a. Significantly enriched GO biological processes of genes. The blue dots in the graph mean upregulated gene. The depth of the inner arc area shows decrease or increase of the biological process. b. Gene correlation between most prominent GO terms. The depth of the color represents the fold change of gene. The area of circle means gene counts. c. GSEA-based GO analysis-enrichment plots of representative gene sets: activation of immune response. The green line means enrichment profile. GO and GSEA analysis was performed by using R package clusterProfiler (version 3.8.1); R package DOSE (version 3.6.1); and R package org. Hs.eg.db (version 3.6.0). The analysis results were visualized by using R package Enrichplot (version 1.2.0) and R package GOplot (version 1.0.2)