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Table 1 The previous studies about core genes in autoimmune disease

From: Immune cell infiltration characteristics and related core genes in lupus nephritis: results from bioinformatic analysis

Gene Tissue Function Author DOI
GPB1 Blood Promotes antimicrobial immunity and cell death. Key mediator of angiostatic effects of inflammation and is induced by interferon (IFN)-α and IFN-γ. Liu, et al. [34] https://doi.org/10.1007/s10067-018-4138-7
CD36 Blood Expresses on the cell surface of monocyte/macrophages and involved in the recognition and uptake of pro-atherogenic oxidized low-density lipoprotein (LDL). Reiss, et al. [35] https://doi.org/10.3181/0806-BC-194
FCER1G Spleen Associated with multiple leukocyte receptor complexes and mediates signal transduction. Sweet, et al. [36] https://doi.org/10.4049/jimmunol.1600861
CLEC7A Blood Involved in the clearance of apoptotic cells, uptake and presentation of cellular antigens and triggers different cytokines and chemokines. Salazar-Aldrete, et al. [37] https://doi.org/10.1007/s10875-012-9821-x
ITGB2 Bone Marrow Encodes integrin β2 protein (CD18). Plays important roles in leukocyte adhesion, immune and inflammatory reactions, immigration through endothelial and chemotaxis. Zimmer, et al. [38] https://doi.org/10.1371/journal.pone.0013351
LILRB4 Blood Associated with increased inflammatory cytokine levels in SLE and is expressed by many leukocytes. Jensen, et al. [39] https://doi.org/10.1136/annrheumdis-2012-202024
HLA − DRA Blood SLE susceptibility genes and plays a central role in the immune system by presenting peptides derived from extracellular proteins. Liu, et al. [40] https://doi.org/10.2174/1566524019666190424130809
PSMB9 Skin Upregulates in the pathophysiology of cutaneous lesions of dermatomyositis and SLE. Nakamura, et al. [41] https://doi.org/10.1111/bjd.14385
BTK Blood Plays an important role in both B cell and FcgammaR mediated myeloid cell activation. BTK inhibition may be a promising treatment approach for lupus nephritis. Kong, et al. [42] https://doi.org/10.1007/s10067-017-3717-3
PYCARD Blood Forms inflammasome complexes mediate the inflammatory and apoptotic signaling pathways. Shin, et al. [43] https://doi.org/10.1002/art.40672
CFP Blood The only positive regulator of the complement system. Recognized apoptotic and necrotic cells. Cohen, et al. [44] https://doi.org/10.1002/path.2893
CFD Blood Encodes a protein functioned as an adipokine that involved in regulation of immune system and inflammatory responses. Chougule, et al. [45] https://doi.org/10.1016/j.cyto.2018.08.002
MARCO Blood Binds to apoptotic cells and contribute to the clearance of apoptotic cells. Chen, et al. [46] https://doi.org/10.1186/ar3230
CD3D Blood Single nucleotide polymorphism in the immune compartment and B cells, also involved in T cell signaling. Lindén, et al. [47] https://doi.org/10.1186/s13293-017-0153-7
PSMB8 Blood Involved in antigen-processing and presentation in naïve CD4 + T cells and hypomethylated in SLE. Renauer, et al. [48] https://doi.org/10.1136/lupus-2015-000101