Table 1 The previous studies about core genes in autoimmune disease
Gene | Tissue | Function | Author | DOI |
|---|---|---|---|---|
GPB1 | Blood | Promotes antimicrobial immunity and cell death. Key mediator of angiostatic effects of inflammation and is induced by interferon (IFN)-α and IFN-γ. | Liu, et al. [34] | |
CD36 | Blood | Expresses on the cell surface of monocyte/macrophages and involved in the recognition and uptake of pro-atherogenic oxidized low-density lipoprotein (LDL). | Reiss, et al. [35] | |
FCER1G | Spleen | Associated with multiple leukocyte receptor complexes and mediates signal transduction. | Sweet, et al. [36] | |
CLEC7A | Blood | Involved in the clearance of apoptotic cells, uptake and presentation of cellular antigens and triggers different cytokines and chemokines. | Salazar-Aldrete, et al. [37] | |
ITGB2 | Bone Marrow | Encodes integrin β2 protein (CD18). Plays important roles in leukocyte adhesion, immune and inflammatory reactions, immigration through endothelial and chemotaxis. | Zimmer, et al. [38] | |
LILRB4 | Blood | Associated with increased inflammatory cytokine levels in SLE and is expressed by many leukocytes. | Jensen, et al. [39] | |
HLA − DRA | Blood | SLE susceptibility genes and plays a central role in the immune system by presenting peptides derived from extracellular proteins. | Liu, et al. [40] | |
PSMB9 | Skin | Upregulates in the pathophysiology of cutaneous lesions of dermatomyositis and SLE. | Nakamura, et al. [41] | |
BTK | Blood | Plays an important role in both B cell and FcgammaR mediated myeloid cell activation. BTK inhibition may be a promising treatment approach for lupus nephritis. | Kong, et al. [42] | |
PYCARD | Blood | Forms inflammasome complexes mediate the inflammatory and apoptotic signaling pathways. | Shin, et al. [43] | |
CFP | Blood | The only positive regulator of the complement system. Recognized apoptotic and necrotic cells. | Cohen, et al. [44] | |
CFD | Blood | Encodes a protein functioned as an adipokine that involved in regulation of immune system and inflammatory responses. | Chougule, et al. [45] | |
MARCO | Blood | Binds to apoptotic cells and contribute to the clearance of apoptotic cells. | Chen, et al. [46] | |
CD3D | Blood | Single nucleotide polymorphism in the immune compartment and B cells, also involved in T cell signaling. | Lindén, et al. [47] | |
PSMB8 | Blood | Involved in antigen-processing and presentation in naïve CD4 + T cells and hypomethylated in SLE. | Renauer, et al. [48] |