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Table 1 The previous studies about core genes in autoimmune disease

From: Immune cell infiltration characteristics and related core genes in lupus nephritis: results from bioinformatic analysis

Gene Tissue Function Author DOI
GPB1 Blood Promotes antimicrobial immunity and cell death. Key mediator of angiostatic effects of inflammation and is induced by interferon (IFN)-α and IFN-γ. Liu, et al. [34]
CD36 Blood Expresses on the cell surface of monocyte/macrophages and involved in the recognition and uptake of pro-atherogenic oxidized low-density lipoprotein (LDL). Reiss, et al. [35]
FCER1G Spleen Associated with multiple leukocyte receptor complexes and mediates signal transduction. Sweet, et al. [36]
CLEC7A Blood Involved in the clearance of apoptotic cells, uptake and presentation of cellular antigens and triggers different cytokines and chemokines. Salazar-Aldrete, et al. [37]
ITGB2 Bone Marrow Encodes integrin β2 protein (CD18). Plays important roles in leukocyte adhesion, immune and inflammatory reactions, immigration through endothelial and chemotaxis. Zimmer, et al. [38]
LILRB4 Blood Associated with increased inflammatory cytokine levels in SLE and is expressed by many leukocytes. Jensen, et al. [39]
HLA − DRA Blood SLE susceptibility genes and plays a central role in the immune system by presenting peptides derived from extracellular proteins. Liu, et al. [40]
PSMB9 Skin Upregulates in the pathophysiology of cutaneous lesions of dermatomyositis and SLE. Nakamura, et al. [41]
BTK Blood Plays an important role in both B cell and FcgammaR mediated myeloid cell activation. BTK inhibition may be a promising treatment approach for lupus nephritis. Kong, et al. [42]
PYCARD Blood Forms inflammasome complexes mediate the inflammatory and apoptotic signaling pathways. Shin, et al. [43]
CFP Blood The only positive regulator of the complement system. Recognized apoptotic and necrotic cells. Cohen, et al. [44]
CFD Blood Encodes a protein functioned as an adipokine that involved in regulation of immune system and inflammatory responses. Chougule, et al. [45]
MARCO Blood Binds to apoptotic cells and contribute to the clearance of apoptotic cells. Chen, et al. [46]
CD3D Blood Single nucleotide polymorphism in the immune compartment and B cells, also involved in T cell signaling. Lindén, et al. [47]
PSMB8 Blood Involved in antigen-processing and presentation in naïve CD4 + T cells and hypomethylated in SLE. Renauer, et al. [48]