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Table 1 B-cell subpopulations in patients with severe chronic kidney disease

From: The effect of pneumococcal immunization on total and antigen-specific B cells in patients with severe chronic kidney disease

B cellsPre-immunization % (CI)Post-immunization % (CI)p value
Total B cells (CD19+)8.6 (7.0–10.6)7.7 (6.9–8.5)>  0.05
Naïve (CD27-IgM+)46.3 (38.8–55.3)42.5 (36.7–49.3)> 0.05
IgM memory (CD27 + IgM+)7.0 (5.2–9.5)7.8 (6.5–9.4)> 0.05
Class Switched (CD27-IgM-)14.3 (12.6–16.3)11.6 (10.1–13.3)> 0.05
Class Switched memory (CD27 + IgM-)17.6 (13.5–23.0)21.4 (18–0-25.6)> 0.05
CD19 + CD5+30.2 (23.9–38.1)24.9 (19.7–31.5)> 0.05
CD19 + CD5-52.0 (39.3–68.7)74.2 (68.5–80.4)< 0.05
  1. Immunophenotype of peripheral blood B cells was determined by flow cytometry pre- and 7 days post-immunization with PCV13. Geometric mean (GM) of proportions with 95% confidence intervals (CI) are shown. For analysis of total B cells, naïve, IgM memory, class switched and class switched memory B cells, 33 pre-immunization and 60 post-immunization samples were studied. CD5 expression analysis, 33 pre-immunization and 39 post-immunization samples were studied. Statistical significance was determined by Mann-Whitney U test