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Table 1 B-cell subpopulations in patients with severe chronic kidney disease

From: The effect of pneumococcal immunization on total and antigen-specific B cells in patients with severe chronic kidney disease

B cells

Pre-immunization % (CI)

Post-immunization % (CI)

p value

Total B cells (CD19+)

8.6 (7.0–10.6)

7.7 (6.9–8.5)

>  0.05

Naïve (CD27-IgM+)

46.3 (38.8–55.3)

42.5 (36.7–49.3)

> 0.05

IgM memory (CD27 + IgM+)

7.0 (5.2–9.5)

7.8 (6.5–9.4)

> 0.05

Class Switched (CD27-IgM-)

14.3 (12.6–16.3)

11.6 (10.1–13.3)

> 0.05

Class Switched memory (CD27 + IgM-)

17.6 (13.5–23.0)

21.4 (18–0-25.6)

> 0.05

CD19 + CD5+

30.2 (23.9–38.1)

24.9 (19.7–31.5)

> 0.05

CD19 + CD5-

52.0 (39.3–68.7)

74.2 (68.5–80.4)

< 0.05

  1. Immunophenotype of peripheral blood B cells was determined by flow cytometry pre- and 7 days post-immunization with PCV13. Geometric mean (GM) of proportions with 95% confidence intervals (CI) are shown. For analysis of total B cells, naïve, IgM memory, class switched and class switched memory B cells, 33 pre-immunization and 60 post-immunization samples were studied. CD5 expression analysis, 33 pre-immunization and 39 post-immunization samples were studied. Statistical significance was determined by Mann-Whitney U test