Fig. 1

IVIg treats chronic inflammatory arthritis optimally at 2 g/kg doses, administered every other day. The clinical scores (a) and paw width measurements (b) are shown for mice treated with multiple doses of 4 g/kg, 2 g/kg or 1 g/kg of IVIg, using HSA-treated mice as a control. Arrows indicate treatment given on days 1, 3, 5, 7, 9, and 11. Shown are the average clinical scores and the average paw width measurements (mm); error bars indicate range of clinical scores/range of paw widths (mean ± SD; n = 4–5 for each treatment group). **P < 0.001 4 g/kg vs. HSA and 2 g/kg IVIg vs. HSA