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Fig. 7 | BMC Immunology

Fig. 7

From: Interactions between Yersinia pestis V-antigen (LcrV) and human Toll-like receptor 2 (TLR2) in a modelled protein complex and potential mechanistic insights

Fig. 7

A proposed mechanistic model for LcrV function in immune repression. Panel (a), regions critical for LcrV-TLR2 complex formation, red color: regions critical for LcrV-TLR2 binding, yellow color: regions critical for LcrV-LcrV binding, the regions not critical to subunit binding are shown in blue; Panel (b), separation of TLR2 C-terminus by LcrV, blue color: LcrV subunits, green color: TLR2 subunits, red color: TLR2 C-terminus; Panel (c), proposed mechanistic model for LcrV in immune response repression, orange color: TLR2, blue color: TLR1, green color: TLR6, light blue color: LcrV, top: when not bound with LcrV, TLR subunits form dimers leading to immune response; bottom: when TLR2 dimers are bound with LcrV forming heterotetramers, TLR2 subunits are separated leading to the loss of immune response and TLR1/6 cannot form dimers with TLR2 which leads to the loss of immune response

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BMC Immunology

ISSN: 1471-2172

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