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Fig. 5 | BMC Immunology

Fig. 5

From: Prostaglandin E2 stimulates COX-2 expression via mitogen-activated protein kinase p38 but not ERK in human follicular dendritic cell-like cells

Fig. 5

Proposed model for the central role of p38 mitogen-activated protein kinase in COX-2 expression in human FDC. The paracrine or autocrine effects of PGE2 are exerted to FDC via EP2 and EP4 receptors. PGE2 promotes COX-2 expression by stimulating the activity of p38 activity and repressing that of Akt. PGs released from FDC take part in the GC reactions in a paracrine fashion to regulate important functions of lymphocytes. For example, PGE2 enhances the survival and antigen-presenting capability of GC B cells

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