TY - JOUR AU - Fransen, M. F. AU - Sluis, T. C. AU - Ossendorp, F. AU - Arens, R. AU - Melief, C. J. M. PY - 2013 DA - 2013// TI - Controlled local delivery of CTLA-4 blocking antibody induces CD8 + T-cell-dependent tumor eradication and decreases risk of toxic side effects JO - Clin Cancer Res VL - 19 UR - https://doi.org/10.1158/1078-0432.CCR-12-0781 DO - 10.1158/1078-0432.CCR-12-0781 ID - Fransen2013 ER - TY - JOUR AU - Redmond, W. L. AU - Linch, S. N. AU - Kasiewicz, M. J. PY - 2014 DA - 2014// TI - Combined targeting of costimulatory (OX40) and coinhibitory (CTLA-4) pathways elicits potent effector T cells capable of driving robust antitumor immunity JO - Cancer Immunol Res VL - 2 UR - https://doi.org/10.1158/2326-6066.CIR-13-0031-T DO - 10.1158/2326-6066.CIR-13-0031-T ID - Redmond2014 ER - TY - JOUR AU - Deng, L. AU - Liang, H. AU - Burnette, B. AU - Beckett, M. AU - Darga, T. AU - Weichselbaum, R. R. PY - 2014 DA - 2014// TI - Irradiation and anti – PD-L1 treatment synergistically promote antitumor immunity in mice JO - J Clin Invest VL - 124 UR - https://doi.org/10.1172/JCI67313 DO - 10.1172/JCI67313 ID - Deng2014 ER - TY - JOUR AU - Wu, A. A. AU - Drake, V. AU - Huang, H. S. AU - Chiu, S. C. AU - Zheng, L. PY - 2015 DA - 2015// TI - Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells JO - Oncoimmunology VL - 4 UR - https://doi.org/10.1080/2162402X.2015.1016700 DO - 10.1080/2162402X.2015.1016700 ID - Wu2015 ER - TY - JOUR AU - Su, S. AU - Liao, J. AU - Liu, J. AU - Huang, D. AU - He, C. AU - Chen, F. PY - 2017 DA - 2017// TI - Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer JO - Cell Res VL - 27 UR - https://doi.org/10.1038/cr.2017.34 DO - 10.1038/cr.2017.34 ID - Su2017 ER - TY - STD TI - Wiedemann GM, Knott MML, Vetter VK, Rapp M, Haubner S, Fesseler J, et al. Cancer cell-derived IL-1α induces CCL22 and the recruitment of regulatory T cells. Oncoimmunology. 2016;5(9):1–11. ID - ref6 ER - TY - JOUR AU - Smigiel, K. S. AU - Srivastava, S. AU - Stolley, J. M. AU - Campbell, D. J. PY - 2014 DA - 2014// TI - Regulatory T cell homeostasis: steady-state maintenance and modulation during inflammation JO - Immunol Rev VL - 259 UR - https://doi.org/10.1111/imr.12170 DO - 10.1111/imr.12170 ID - Smigiel2014 ER - TY - STD TI - Hori S, Nomura T, Sakaguchi S. Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science. 2003;299(5609):1057–61. ID - ref8 ER - TY - JOUR AU - Valzasina, B. AU - Piconese, S. AU - Guiducci, C. AU - Colombo, M. P. PY - 2006 DA - 2006// TI - Tumor-induced expansion of regulatory T cells by conversion of CD4+CD25- lymphocytes is thymus and proliferation independent JO - Cancer Res VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-05-4217 DO - 10.1158/0008-5472.CAN-05-4217 ID - Valzasina2006 ER - TY - JOUR AU - Zhou, G. AU - Levitsky, H. I. PY - 2007 DA - 2007// TI - Natural regulatory T cells and De novo-induced regulatory T cells contribute independently to tumor-specific tolerance JO - J Immunol VL - 178 UR - https://doi.org/10.4049/jimmunol.178.4.2155 DO - 10.4049/jimmunol.178.4.2155 ID - Zhou2007 ER - TY - JOUR AU - Viguier, M. AU - Lemaître, F. AU - Verola, O. AU - Cho, M. -. S. AU - Gorochov, G. AU - Dubertret, L. PY - 2004 DA - 2004// TI - Foxp3 expressing CD4 + CD25 high regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells JO - J Immunol VL - 173 UR - https://doi.org/10.4049/jimmunol.173.2.1444 DO - 10.4049/jimmunol.173.2.1444 ID - Viguier2004 ER - TY - JOUR AU - Miller, A. M. AU - Lundberg, K. AU - Özenci, V. AU - Banham, A. H. AU - Hellström, M. AU - Egevad, L. PY - 2006 DA - 2006// TI - CD4+CD25 high T cells are enriched in the tumor and peripheral blood of prostate Cancer patients JO - J Immunol VL - 177 UR - https://doi.org/10.4049/jimmunol.177.10.7398 DO - 10.4049/jimmunol.177.10.7398 ID - Miller2006 ER - TY - JOUR AU - Mizukami, Y. AU - Kono, K. AU - Kawaguchi, Y. AU - Akaike, H. AU - Kamimura, K. AU - Sugai, H. PY - 2008 DA - 2008// TI - CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer JO - Int J Cancer VL - 122 UR - https://doi.org/10.1002/ijc.23392 DO - 10.1002/ijc.23392 ID - Mizukami2008 ER - TY - JOUR AU - Ward, S. T. AU - Li, K. K. AU - Hepburn, E. AU - Weston, C. J. AU - Curbishley, S. M. AU - Reynolds, G. M. PY - 2015 DA - 2015// TI - The effects of CCR5 inhibition on regulatory T-cell recruitment to colorectal cancer JO - Br J Cancer VL - 112 UR - https://doi.org/10.1038/bjc.2014.572 DO - 10.1038/bjc.2014.572 ID - Ward2015 ER - TY - JOUR AU - Kuehnemuth, B. AU - Piseddu, I. AU - Wiedemann, G. M. AU - Lauseker, M. AU - Kuhn, C. AU - Hofmann, S. PY - 2018 DA - 2018// TI - CCL1 is a major regulatory T cell attracting factor in human breast cancer JO - BMC Cancer VL - 18 UR - https://doi.org/10.1186/s12885-018-5117-8 DO - 10.1186/s12885-018-5117-8 ID - Kuehnemuth2018 ER - TY - JOUR AU - Liu, V. C. AU - Wong, L. Y. AU - Jang, T. AU - Shah, A. H. AU - Park, I. AU - Yang, X. PY - 2007 DA - 2007// TI - Tumor evasion of the immune system by converting CD4+ CD25− T cells into CD4+ CD25+ T regulatory cells: role of tumor-derived TGF-β JO - J Immunol VL - 178 UR - https://doi.org/10.4049/jimmunol.178.5.2883 DO - 10.4049/jimmunol.178.5.2883 ID - Liu2007 ER - TY - JOUR AU - Mittal, S. AU - Marshall, N. A. AU - Duncan, L. AU - Culligan, D. J. AU - Barker, R. N. AU - Vickers, M. A. PY - 2008 DA - 2008// TI - Local and systemic induction of CD4+CD25+ regulatory T-cell population by non-Hodgkin lymphoma JO - Blood VL - 111 UR - https://doi.org/10.1182/blood-2007-08-105395 DO - 10.1182/blood-2007-08-105395 ID - Mittal2008 ER - TY - STD TI - Floess S, Freyer J, Siewert C, Baron U, Olek S, Polansky J, et al. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol. 2007;5(2):e38. ID - ref18 ER - TY - JOUR AU - Deaglio, S. AU - Dwyer, K. M. AU - Gao, W. AU - Friedman, D. AU - Usheva, A. AU - Erat, A. PY - 2007 DA - 2007// TI - Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression JO - J Exp Med VL - 204 UR - https://doi.org/10.1084/jem.20062512 DO - 10.1084/jem.20062512 ID - Deaglio2007 ER - TY - JOUR AU - Huang, C. T. AU - Workman, C. J. AU - Flies, D. AU - Pan, X. AU - Marson, A. L. AU - Zhou, G. PY - 2004 DA - 2004// TI - Role of LAG-3 in regulatory T cells JO - Immunity. VL - 21 UR - https://doi.org/10.1016/j.immuni.2004.08.010 DO - 10.1016/j.immuni.2004.08.010 ID - Huang2004 ER - TY - STD TI - Wu SP, Liao RQ, Tu HY, Wang WJ, Dong ZY, Huang SM, et al. Stromal PD-L1–positive regulatory T cells and PD-1–positive CD8-positive T cells define the response of different subsets of non–small cell lung Cancer to PD-1/PD-L1 blockade immunotherapy. J Thorac Oncol. 2018;13(4):521–32. ID - ref21 ER - TY - JOUR AU - Jarosz-Biej, M. AU - Smolarczyk, R. AU - Cichoń, T. AU - Kułach, N. PY - 2019 DA - 2019// TI - Tumor microenvironment as a “game changer” in Cancer radiotherapy JO - Int J Mol Sci VL - 20 UR - https://doi.org/10.3390/ijms20133212 DO - 10.3390/ijms20133212 ID - Jarosz-Biej2019 ER - TY - JOUR AU - Garnett, C. T. AU - Palena, C. AU - Chakarborty, M. AU - Tsang, K. Y. AU - Schlom, J. AU - Hodge, J. W. PY - 2004 DA - 2004// TI - Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes JO - Cancer Res VL - 64 UR - https://doi.org/10.1158/0008-5472.CAN-04-1525 DO - 10.1158/0008-5472.CAN-04-1525 ID - Garnett2004 ER - TY - STD TI - Ifeadi V, Garnett-Benson C. Sub-lethal irradiation of human colorectal tumor cells imparts enhanced and sustained susceptibility to multiple death receptor signaling pathways. PLoS One. 2012;7(2):e31762. ID - ref24 ER - TY - JOUR AU - Kumari, A. AU - Garnett-Benson, C. PY - 2016 DA - 2016// TI - Effector function of CTLs is increased by irradiated colorectal tumor cells that modulate OX-40L and 4-1BBL and is reversed following dual blockade JO - BMC Res Notes VL - 9 UR - https://doi.org/10.1186/s13104-016-1914-9 DO - 10.1186/s13104-016-1914-9 ID - Kumari2016 ER - TY - JOUR AU - Spary, L. K. AU - Al-Taei, S. AU - Salimu, J. AU - Cook, A. D. AU - Ager, A. AU - Watson, H. A. PY - 2014 DA - 2014// TI - Enhancement of T cell responses as a result of synergy between lower doses of radiation and T cell stimulation JO - J Immunol VL - 192 UR - https://doi.org/10.4049/jimmunol.1302736 DO - 10.4049/jimmunol.1302736 ID - Spary2014 ER - TY - JOUR AU - Lee, Y. AU - Auh, S. L. AU - Wang, Y. AU - Burnette, B. AU - Wang, Y. AU - Meng, Y. PY - 2009 DA - 2009// TI - Therapeutic effects of ablative radiation on local tumor require CD8 + T cells: changing strategies for cancer treatment JO - Blood VL - 114 UR - https://doi.org/10.1182/blood-2009-02-206870 DO - 10.1182/blood-2009-02-206870 ID - Lee2009 ER - TY - JOUR AU - Filatenkov, A. AU - Baker, J. AU - Mueller, A. M. S. AU - Kenkel, J. AU - Ahn, G. O. AU - Dutt, S. PY - 2015 DA - 2015// TI - Ablative tumor radiation can change the tumor immune cell microenvironment to induce durable complete remissions JO - Clin Cancer Res VL - 21 UR - https://doi.org/10.1158/1078-0432.CCR-14-2824 DO - 10.1158/1078-0432.CCR-14-2824 ID - Filatenkov2015 ER - TY - STD TI - Golden EB, Apetoh L. Radiotherapy and immunogenic cell death. Semin Radiat Oncol. 2015;25(1):11–7. ID - ref29 ER - TY - STD TI - Buchwald ZS, Wynne J, Nasti TH, Zhu S, Mourad WF, Yan W, et al. Radiation, immune checkpoint blockade and the abscopal effect: a critical review on timing, dose and fractionation. Front Oncol. 2018;8:612. ID - ref30 ER - TY - JOUR AU - Rodriguez-Ruiz, M. E. AU - Vanpouille-Box, C. AU - Melero, I. AU - Formenti, S. C. AU - Demaria, S. PY - 2018 DA - 2018// TI - Immunological mechanisms responsible for radiation-induced abscopal effect JO - Trends Immunol VL - 39 UR - https://doi.org/10.1016/j.it.2018.06.001 DO - 10.1016/j.it.2018.06.001 ID - Rodriguez-Ruiz2018 ER - TY - JOUR AU - Dewan, M. Z. AU - Galloway, A. E. AU - Kawashima, N. AU - Dewyngaert, J. K. AU - Babb, J. S. AU - Formenti, S. C. PY - 2009 DA - 2009// TI - Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody JO - Clin Cancer Res VL - 15 UR - https://doi.org/10.1158/1078-0432.CCR-09-0265 DO - 10.1158/1078-0432.CCR-09-0265 ID - Dewan2009 ER - TY - JOUR AU - Niknam, S. AU - Barsoumian, H. B. AU - Schoenhals, J. E. AU - Jackson, H. L. AU - Yanamandra, N. AU - Caetano, M. S. PY - 2018 DA - 2018// TI - Radiation followed by OX40 stimulation drives local and abscopal antitumor effects in an anti–PD1-resistant lung tumor model JO - Clin Cancer Res VL - 24 UR - https://doi.org/10.1158/1078-0432.CCR-17-3279 DO - 10.1158/1078-0432.CCR-17-3279 ID - Niknam2018 ER - TY - JOUR AU - Qu, Y. AU - Jin, S. AU - Zhang, A. AU - Zhang, B. AU - Shi, X. AU - Wang, J. PY - 2010 DA - 2010// TI - Gamma-ray resistance of regulatory CD4 + CD25 + Foxp3 + T cells in mice JO - Radiat Res VL - 173 UR - https://doi.org/10.1667/RR0978.1 DO - 10.1667/RR0978.1 ID - Qu2010 ER - TY - JOUR AU - Baba, J. AU - Watanabe, S. AU - Saida, Y. AU - Tanaka, T. AU - Miyabayashi, T. AU - Koshio, J. PY - 2012 DA - 2012// TI - Depletion of radio-resistant regulatory T cells enhances antitumor immunity during recovery from lymphopenia JO - Blood VL - 120 UR - https://doi.org/10.1182/blood-2012-02-411124 DO - 10.1182/blood-2012-02-411124 ID - Baba2012 ER - TY - JOUR AU - Qu, Y. AU - Zhang, B. AU - Liu, S. AU - Zhang, A. AU - Wu, T. AU - Zhao, Y. PY - 2010 DA - 2010// TI - 2-Gy whole-body irradiation significantly alters the balance of CD4 +CD25-T effector cells and CD4+CD25 +Foxp3+ T regulatory cells in mice JO - Cell Mol Immunol VL - 7 UR - https://doi.org/10.1038/cmi.2010.45 DO - 10.1038/cmi.2010.45 ID - Qu2010 ER - TY - JOUR AU - Balogh, A. AU - Persa, E. AU - Bogdándi, E. N. AU - Benedek, A. AU - Hegyesi, H. AU - Sáfrány, G. PY - 2013 DA - 2013// TI - The effect of ionizing radiation on the homeostasis and functional integrity of murine splenic regulatory T cells JO - Inflamm Res VL - 62 UR - https://doi.org/10.1007/s00011-012-0567-y DO - 10.1007/s00011-012-0567-y ID - Balogh2013 ER - TY - JOUR AU - Billiard, F. AU - Buard, V. AU - Benderitter, M. AU - Linard, C. PY - 2011 DA - 2011// TI - Abdominal γ-radiation induces an accumulation of function-impaired regulatory T cells in the small intestine JO - Int J Radiat Oncol Biol Phys VL - 80 UR - https://doi.org/10.1016/j.ijrobp.2010.12.041 DO - 10.1016/j.ijrobp.2010.12.041 ID - Billiard2011 ER - TY - JOUR AU - Muroyama, Y. AU - Nirschl, T. R. AU - Kochel, C. M. AU - Lopez-Bujanda, Z. AU - Theodros, D. AU - Mao, W. PY - 2017 DA - 2017// TI - Stereotactic radiotherapy increases functionally suppressive regulatory T cells in the tumor microenvironment JO - Cancer Immunol Res VL - 5 UR - https://doi.org/10.1158/2326-6066.CIR-17-0040 DO - 10.1158/2326-6066.CIR-17-0040 ID - Muroyama2017 ER - TY - JOUR AU - Kachikwu, E. L. AU - Iwamoto, K. S. AU - Liao, Y. P. AU - Demarco, J. J. AU - Agazaryan, N. AU - Economou, J. S. PY - 2011 DA - 2011// TI - Radiation enhances regulatory T cell representation JO - Int J Radiat Oncol Biol Phys VL - 81 UR - https://doi.org/10.1016/j.ijrobp.2010.09.034 DO - 10.1016/j.ijrobp.2010.09.034 ID - Kachikwu2011 ER - TY - JOUR AU - Cao, M. AU - Cabrera, R. AU - Xu, Y. AU - Liu, C. AU - Nelson, D. PY - 2009 DA - 2009// TI - Gamma irradiation alters the phenotype and function of CD4+CD25+ regulatory T cells JO - Cell Biol Int VL - 33 UR - https://doi.org/10.1016/j.cellbi.2009.02.007 DO - 10.1016/j.cellbi.2009.02.007 ID - Cao2009 ER - TY - STD TI - Liu R, Xiong S, Zhang L, Chu Y. Enhancement of antitumor immunity by low-dose total body irradiation is associated with selectively decreasing the proportion and number of T regulatory cells. Cell Mol Immunol. 2010;7(2):157–62. ID - ref42 ER - TY - JOUR AU - Anderson, B. E. AU - McNiff, J. M. AU - Matte, C. AU - Athanasiadis, I. AU - Shlomchik, W. D. AU - Shlomchik, M. J. PY - 2004 DA - 2004// TI - Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease JO - Blood VL - 104 UR - https://doi.org/10.1182/blood-2004-01-0328 DO - 10.1182/blood-2004-01-0328 ID - Anderson2004 ER - TY - JOUR AU - Komatsu, N. AU - Hori, S. PY - 2007 DA - 2007// TI - Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras JO - Proc Natl Acad Sci U S A VL - 104 UR - https://doi.org/10.1073/pnas.0702004104 DO - 10.1073/pnas.0702004104 ID - Komatsu2007 ER - TY - JOUR AU - Cao, M. AU - Cabrera, R. AU - Xu, Y. AU - Liu, C. AU - Nelson, D. PY - 2011 DA - 2011// TI - Different radiosensitivity of CD4+CD25+ regulatory T cells and effector T cells to low dose gamma irradiation in vitro JO - Int J Radiat Biol VL - 87 UR - https://doi.org/10.3109/09553002.2010.518208 DO - 10.3109/09553002.2010.518208 ID - Cao2011 ER - TY - JOUR AU - Schmidt, A. AU - Eriksson, M. AU - Shang, M. M. AU - Weyd, H. AU - Tegnér, J. PY - 2016 DA - 2016// TI - Comparative analysis of protocols to induce human CD4+Foxp3+ regulatory T cells by combinations of IL-2, TGF-beta, retinoic acid, rapamycin and butyrate JO - PLoS One VL - 11 ID - Schmidt2016 ER - TY - STD TI - Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell. 2008;133(5):775–87. ID - ref47 ER - TY - STD TI - Zhou L, Chong MMW, Littman DR. Plasticity of CD4+ T cell lineage differentiation. Immunity. 2009;30(5):646–55. ID - ref48 ER - TY - JOUR AU - Wei, G. AU - Wei, L. AU - Zhu, J. AU - Zang, C. AU - Hu-li, J. AU - Yao, Z. PY - 2009 DA - 2009// TI - Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells JO - Immunity VL - 30 UR - https://doi.org/10.1016/j.immuni.2008.12.009 DO - 10.1016/j.immuni.2008.12.009 ID - Wei2009 ER - TY - STD TI - Haribhai D, Williams JB, Jia S, Nickerson D, Schmitt EG, Edwards B, et al. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity. 2011;35(1):109–22. ID - ref50 ER - TY - JOUR AU - Chakir, H. AU - Wang, H. AU - Lefebvre, D. E. AU - Webb, J. AU - Scott, F. W. PY - 2003 DA - 2003// TI - T-bet/GATA-3 ratio as a measure of the Th1/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3 JO - J Immunol Methods VL - 278 UR - https://doi.org/10.1016/S0022-1759(03)00200-X DO - 10.1016/S0022-1759(03)00200-X ID - Chakir2003 ER - TY - JOUR AU - Butcher, M. J. AU - Filipowicz, A. R. AU - Waseem, T. C. AU - McGary, C. M. AU - Crow, K. J. AU - Magilnick, N. PY - 2016 DA - 2016// TI - Atherosclerosis-driven Treg plasticity results in formation of a dysfunctional subset of plastic IFNγ+ Th1/Tregs JO - Circ Res VL - 119 UR - https://doi.org/10.1161/CIRCRESAHA.116.309764 DO - 10.1161/CIRCRESAHA.116.309764 ID - Butcher2016 ER - TY - STD TI - Camperio C, Caristi S, Fanelli G, Soligo M, De Porto P, Piccolella E. Forkhead Transcription Factor FOXP3 Upregulates CD25 Expression through Cooperation with RelA/NF-κB. PLoS One. 2012;7(10):e48303. ID - ref53 ER - TY - JOUR AU - Kolar, P. AU - Knieke, K. AU - Hegel, J. K. E. AU - Quandt, D. AU - Burmester, G. R. AU - Hoff, H. PY - 2009 DA - 2009// TI - CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice JO - Arthritis Rheum VL - 60 UR - https://doi.org/10.1002/art.24181 DO - 10.1002/art.24181 ID - Kolar2009 ER - TY - JOUR AU - Onishi, Y. AU - Fehervari, Z. AU - Yamaguchi, T. AU - Sakaguchi, S. PY - 2008 DA - 2008// TI - Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation JO - Proc Natl Acad Sci U S A VL - 105 UR - https://doi.org/10.1073/pnas.0711106105 DO - 10.1073/pnas.0711106105 ID - Onishi2008 ER - TY - JOUR AU - Liang, B. AU - Workman, C. AU - Lee, J. AU - Chew, C. AU - Dale, B. M. AU - Colonna, L. PY - 2008 DA - 2008// TI - Regulatory T cells inhibit dendritic cells by lymphocyte activation Gene-3 engagement of MHC class II JO - J Immunol VL - 180 UR - https://doi.org/10.4049/jimmunol.180.9.5916 DO - 10.4049/jimmunol.180.9.5916 ID - Liang2008 ER - TY - JOUR AU - Xie, X. AU - Stubbington, M. J. T. AU - Nissen, J. K. AU - Andersen, K. G. AU - Hebenstreit, D. AU - Teichmann, S. A. PY - 2015 DA - 2015// TI - The regulatory T cell lineage factor Foxp3 regulates gene expression through several distinct mechanisms mostly independent of direct DNA binding JO - PLoS Genet VL - 11 ID - Xie2015 ER - TY - JOUR AU - Sadlon, T. J. AU - Wilkinson, B. G. AU - Pederson, S. AU - Brown, C. Y. AU - Bresatz, S. AU - Gargett, T. PY - 2010 DA - 2010// TI - Genome-wide identification of human FOXP3 target genes in natural regulatory T cells JO - J Immunol VL - 185 UR - https://doi.org/10.4049/jimmunol.1000082 DO - 10.4049/jimmunol.1000082 ID - Sadlon2010 ER - TY - JOUR AU - Huang, W. AU - Solouki, S. AU - Carter, C. AU - Zheng, S. G. AU - August, A. PY - 2018 DA - 2018// TI - Beyond type 1 regulatory t cells: co-expression of LAG3 and CD49b in IL-10-producing T cell lineages JO - Front Immunol VL - 9 UR - https://doi.org/10.3389/fimmu.2018.00001 DO - 10.3389/fimmu.2018.00001 ID - Huang2018 ER - TY - JOUR AU - Kumari, A. AU - Simon, S. S. AU - Moody, T. D. AU - Garnett-Benson, C. PY - 2016 DA - 2016// TI - Immunomodulatory effects of radiation: what is next for cancer therapy? JO - Future Oncol VL - 12 UR - https://doi.org/10.2217/fon.15.300 DO - 10.2217/fon.15.300 ID - Kumari2016 ER - TY - JOUR AU - Nakamura, N. AU - Kusunoki, Y. AU - Akiyama, M. PY - 1990 DA - 1990// TI - Radiosensitivity of CD4 or CD8 positive human T-lymphocytes by an in vitro Colony formation assay JO - Radiat Res VL - 123 UR - https://doi.org/10.2307/3577549 DO - 10.2307/3577549 ID - Nakamura1990 ER - TY - STD TI - Lee W, Lee GR. Transcriptional regulation and development of regulatory T cells. Exp Mol Med. 2018;50(3):e456. ID - ref62 ER - TY - JOUR AU - Kumari, A. AU - Cacan, E. AU - Greer, S. F. AU - Garnett-Benson, C. PY - 2013 DA - 2013// TI - Turning T cells on: epigenetically enhanced expression of effector T-cell costimulatory molecules on irradiated human tumor cells JO - J Immunother Cancer VL - 1 UR - https://doi.org/10.1186/2051-1426-1-17 DO - 10.1186/2051-1426-1-17 ID - Kumari2013 ER - TY - JOUR AU - Cacan, E. AU - Greer, S. F. AU - Garnett-Benson, C. PY - 2015 DA - 2015// TI - Radiation-induced modulation of immunogenic genes in tumor cells is regulated by both histone deacetylases and DNA methyltransferases JO - Int J Oncol VL - 47 UR - https://doi.org/10.3892/ijo.2015.3192 DO - 10.3892/ijo.2015.3192 ID - Cacan2015 ER - TY - STD TI - Miousse IR, Kutanzi KR, Koturbash I. Effects of ionizing radiation on DNA methylation: From experimental biology to clinical applications. Int J Radiat Biol. 2017;93(5):457–69. ID - ref65 ER - TY - JOUR AU - Chen, Q. AU - Kim, Y. C. AU - Laurence, A. AU - Punkosdy, G. A. AU - Shevach, E. M. PY - 2011 DA - 2011// TI - IL-2 controls the stability of Foxp3 expression in TGF-β–induced Foxp3 + T cells in vivo JO - J Immunol VL - 186 UR - https://doi.org/10.4049/jimmunol.1100061 DO - 10.4049/jimmunol.1100061 ID - Chen2011 ER - TY - JOUR AU - Goldstein, J. D. AU - Burlion, A. AU - Zaragoza, B. AU - Sendeyo, K. AU - Polansky, J. K. AU - Huehn, J. PY - 2016 DA - 2016// TI - Inhibition of the JAK/STAT signaling pathway in regulatory T cells reveals a very dynamic regulation of foxp3 expression JO - PLoS One VL - 11 ID - Goldstein2016 ER - TY - JOUR AU - Bazhin, A. V. AU - Ahn, K. AU - Fritz, J. AU - Werner, J. AU - Karakhanova, S. PY - 2018 DA - 2018// TI - Interferon-α up-regulates the expression of PD-L1 molecules on immune cells through STAT3 and p38 signaling JO - Front Immunol VL - 9 UR - https://doi.org/10.3389/fimmu.2018.02129 DO - 10.3389/fimmu.2018.02129 ID - Bazhin2018 ER - TY - STD TI - Amarnath S, Costanzo CM, Mariotti J, Ullman JL, Telford WG, Kapoor V, et al. Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1. PLoS Biol. 2010;8(2):e1000302. ID - ref69 ER - TY - JOUR AU - Regateiro, F. S. AU - Howie, D. AU - Nolan, K. F. AU - Agorogiannis, E. I. AU - Greaves, D. R. AU - Cobbold, S. P. PY - 2011 DA - 2011// TI - Generation of anti-inflammatory adenosine byleukocytes is regulated by TGF-β JO - Eur J Immunol VL - 41 UR - https://doi.org/10.1002/eji.201141512 DO - 10.1002/eji.201141512 ID - Regateiro2011 ER - TY - JOUR AU - Peres, R. S. AU - Donate, P. B. AU - Talbot, J. AU - Cecilio, N. T. AU - Lobo, P. R. AU - Machado, C. C. PY - 2018 DA - 2018// TI - TGF-β signalling defect is linked to low CD39 expression on regulatory T cells and methotrexate resistance in rheumatoid arthritis JO - J Autoimmun VL - 90 UR - https://doi.org/10.1016/j.jaut.2018.01.004 DO - 10.1016/j.jaut.2018.01.004 ID - Peres2018 ER - TY - JOUR AU - Sim, G. C. AU - Martin-Orozco, N. AU - Jin, L. AU - Yang, Y. AU - Wu, S. AU - Washington, E. PY - 2014 DA - 2014// TI - IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients JO - J Clin Invest VL - 124 UR - https://doi.org/10.1172/JCI46266 DO - 10.1172/JCI46266 ID - Sim2014 ER - TY - JOUR AU - Morisada, M. AU - Clavijo, P. E. AU - Moore, E. AU - Sun, L. AU - Chamberlin, M. AU - Waes, C. PY - 2018 DA - 2018// TI - PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation JO - Oncoimmunology VL - 7 UR - https://doi.org/10.1080/2162402X.2017.1395996 DO - 10.1080/2162402X.2017.1395996 ID - Morisada2018 ER - TY - STD TI - Vanpouille-Box C, Alard A, Aryankalayil MJ, Sarfraz Y, Diamond JM, Schneider RJ, et al. DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity. Nat Commun. 2017;8:15618. ID - ref74 ER - TY - STD TI - Sridharan V, Margalit DN, Lynch SA, Severgnini M, Zhou J, Chau NG, et al. Definitive chemoradiation alters the immunologic landscape and immune checkpoints in head and neck cancer. Br J Cancer. 2016;115(2):252–60. ID - ref75 ER - TY - JOUR AU - Okamura, T. AU - Fujio, K. AU - Shibuya, M. AU - Sumitomo, S. AU - Shoda, H. AU - Sakaguchi, S. PY - 2009 DA - 2009// TI - CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2 JO - Proc Natl Acad Sci U S A VL - 106 UR - https://doi.org/10.1073/pnas.0906872106 DO - 10.1073/pnas.0906872106 ID - Okamura2009 ER - TY - JOUR AU - Durham, N. M. AU - Nirschl, C. J. AU - Jackson, C. M. AU - Elias, J. AU - Kochel, C. M. AU - Anders, R. A. PY - 2014 DA - 2014// TI - Lymphocyte activation gene 3 (LAG-3) modulates the ability of CD4 T-cells to be suppressed in vivo JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0109080 DO - 10.1371/journal.pone.0109080 ID - Durham2014 ER - TY - JOUR AU - Grosso, J. F. AU - Kelleher, C. C. AU - Harris, T. J. AU - Maris, C. H. AU - Hipkiss, E. L. AU - Marzo, A. PY - 2007 DA - 2007// TI - LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems JO - J Clin Invest VL - 117 UR - https://doi.org/10.1172/JCI31184 DO - 10.1172/JCI31184 ID - Grosso2007 ER - TY - JOUR AU - Lichtenegger, F. S. AU - Rothe, M. AU - Schnorfeil, F. M. AU - Deiser, K. AU - Krupka, C. AU - Augsberger, C. PY - 2018 DA - 2018// TI - Targeting LAG-3 and PD-1 to enhance T cell activation by antigen-presenting cells JO - Front Immunol VL - 9 ID - Lichtenegger2018 ER - TY - STD TI - Zhang Q, Chikina M, Szymczak-Workman AL, Horne W, Kolls JK, Vignali KM, et al. LAG-3 limits regulatory T cell proliferation and function in autoimmune diabetes. Sci Immunol. 2017;2(9):eaah4569. ID - ref80 ER - TY - JOUR AU - Venken, K. AU - Thewissen, M. AU - Hellings, N. AU - Somers, V. AU - Hensen, K. AU - Rummens, J. L. PY - 2007 DA - 2007// TI - A CFSE based assay for measuring CD4+CD25+ regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses JO - J Immunol Methods VL - 322 UR - https://doi.org/10.1016/j.jim.2007.01.025 DO - 10.1016/j.jim.2007.01.025 ID - Venken2007 ER -