Fig. 6
From: Association of circulating SLAMF7+Tfh1 cells with IgG4 levels in patients with IgG4-related disease
The hypothetical model in this study. Activated Tfh2 cells promote IgG4 production via interacting with naïve B cells, whereas SLAMF7+ activated Tfh1 cells positive for PD-1 and CD28 do so via interacting with IgG4-memory B cells. Homotypic engagement of SLAMF7 between T and B cells is also depicted. Tfh: follicular helper CD4+ T; SLAMF7: Signaling Lymphocyte Activation Molecule Family member 7; PD-1: Programmed cell death 1; HLA: Human Leukocyte Antigen; BCR: B-cell receptor; TCR: T-cell receptor